大叶性肺炎中的肺炎球菌抗原
Pneumococcal antigen in lobar pneumonia.
作者信息
Tugwell P, Greenwood B M
出版信息
J Clin Pathol. 1975 Feb;28(2):118-23. doi: 10.1136/jcp.28.2.118.
Abstract
This paper describes the value in diagnosis and the clinical implications of the detection of pneumococcal antigen in patients with lobar pneumonia. Ninety-eight patients with lobar pneumonia were investigated. Pneumococcal antigen was detected by counter-current immunoelectrophoresis in the sputum of 79% of patients with purulent sputum, in the serum of 29% of the patients, and in the urine of 54% of the patients. The diagnostic value of counter-current immunoelectrophoresis was not affected by prior antibiotic therapy. Patients with antigenaemia had a higher incidence of complications than those without as shown by an association between antigenaemia and jaundice, diarrhoea, and persistent pyrexia. Antigen persisted in the circulation for at least seven days in half the patients studied, possibly indicating the development of immunological tolerance to the polysaccharide antigen.
摘要
本文描述了大叶性肺炎患者肺炎球菌抗原检测的诊断价值及临床意义。对98例大叶性肺炎患者进行了研究。通过对流免疫电泳检测发现，79%有脓性痰的患者痰液中、29%的患者血清中以及54%的患者尿液中存在肺炎球菌抗原。对流免疫电泳的诊断价值不受先前抗生素治疗的影响。与无抗原血症的患者相比，有抗原血症的患者并发症发生率更高，抗原血症与黄疸、腹泻和持续发热之间存在关联表明了这一点。在一半的研究患者中，抗原在循环中持续至少7天，这可能表明对多糖抗原产生了免疫耐受性。
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