UJF-Grenoble 1, Grenoble, France; Department of Ophthalmology, CHU Grenoble, Grenoble, France.
Acta Ophthalmol. 2014 Mar;92(2):e119-23. doi: 10.1111/aos.12241. Epub 2013 Jul 15.
To evaluate the effect of overnight wear of the Triggerfish(®) contact lens sensor (CLS) on central corneal thickness (CCT) using the Visante(®) anterior segment optical coherence tomography (AS-OCT).
Twelve healthy subjects were studied in a sleep laboratory. An ophthalmic examination including ultrasonic CCT, corneal topography, specular microscopy and AS-OCT CCT was performed. Starting at 7 pm, the Triggerfish(®) CLS was fitted on one randomly selected eye. Similar AS-OCT measurements were taken on both eyes every 2 hr from 8 pm to 8 am. The CLS was removed just after the 8 am measurement session. Measurements were repeated at 9 am.
Twenty-four eyes of 12 subjects were studied (mean age, 22.1 ± 2.4 years; four men/eight women). CCT significantly increased during the night in both CLS and control eyes (p < 0.01). The maximal change was +4.4 ± 1.7% in the CLS eyes and +2.9 ± 1.8% in the control eyes (p < 0.05). Throughout the night, CCT significantly increased more in eyes with CLS than in control eyes (p < 0.05). There were significantly more corneal curvature irregularities after overnight wear of the CLS than in the control eye: +1.63 Dioptre (D) versus -0.02 D in the 3-mm central zone and +3.17 D versus +0.01 D in the 5-mm central zone (p < 0.01).
CCT and corneal curvature irregularities increased slightly but significantly more in eyes with the Triggerfish(®) CLS than in control eyes during overnight wear. Further studies are required to determine whether the corneal curvature changes modify the signal recorded by the sensor.
使用 Visante®眼前节光学相干断层扫描仪（AS-OCT）评估 Triggerfish（®）角膜接触镜传感器（CLS）过夜佩戴对中央角膜厚度（CCT）的影响。
12 名健康受试者在睡眠实验室进行研究。进行眼科检查，包括超声 CCT、角膜地形图、共焦显微镜和 AS-OCT CCT。晚上 7 点开始，将 Triggerfish（®）CLS 随机戴在一只眼睛上。晚上 8 点至早上 8 点，每 2 小时对双眼进行类似的 AS-OCT 测量。早上 8 点测量后立即取下 CLS。早上 9 点重复测量。
研究了 12 名受试者的 24 只眼睛（平均年龄 22.1±2.4 岁；4 名男性/8 名女性）。CLS 和对照眼的 CCT 在夜间均显著增加（p<0.01）。CLS 眼的最大变化为+4.4±1.7%，对照眼为+2.9±1.8%（p<0.05）。整个夜间，CLS 眼的 CCT 增加明显高于对照眼（p<0.05）。CLS 过夜佩戴后，角膜曲率不规则明显多于对照眼：中央 3mm 区增加+1.63 屈光度（D），对照眼为-0.02 D；中央 5mm 区增加+3.17 D，对照眼为+0.01 D（p<0.01）。
与对照眼相比，Triggerfish（®）CLS 眼在夜间佩戴期间 CCT 和角膜曲率不规则略有但明显增加。需要进一步研究以确定角膜曲率变化是否会改变传感器记录的信号。
