Environ Sci Pollut Res Int. 2014 Feb;21(4):2448-54. doi: 10.1007/s11356-013-2169-9.
The growing need to evaluate the quality of aquatic ecosystems led to the development of numerous monitoring tools. Among them, the development of biomarker-based procedures, that combine precocity and relevance, is recommended. However, multi-biomarker approaches are often hard to interpret, and produce results that are not easy to integrate in the environmental policies framework. Integrative index have been developed, and one of the most used is the integrated biomarker response (IBR). However, an analysis of available literature demonstrated that the IBR suffers from a frequent misuse and a bias in its calculation. Then, we propose here a new calculation method based on both a more simple formula and a permutation procedure. Together, these improvements should rightly avoid the misuse and bias that were recorded. Additionally, a case study illustrates how the new procedure enabled to perform a reliable classification of site along a pollution gradient based on biomarker responses used in the IBR calculations.
对水生生态系统质量进行评估的需求日益增长，这促使了众多监测工具的发展。其中，推荐使用结合了早熟性和相关性的基于生物标志物的程序。然而，多生物标志物方法通常难以解释，并且产生的结果不易整合到环境政策框架中。因此，已经开发了综合指数，其中最常用的是综合生物标志物响应（IBR）。然而，对现有文献的分析表明，IBR 经常被错误使用并且在计算过程中存在偏差。因此，我们在这里提出了一种新的计算方法，该方法基于更简单的公式和置换程序。这些改进措施应能正确避免已记录的误用和偏差。此外，案例研究说明了新方法如何能够根据 IBR 计算中使用的生物标志物响应，可靠地对沿污染梯度的站点进行分类。
