1 The Shraga Segal Department of Microbiology, Immunology and Genetics, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev , Beer-Sheva, Israel .
Rejuvenation Res. 2014 Apr;17(2):134-9. doi: 10.1089/rej.2013.1509. Epub 2014 Apr 8.
Plants growing in the Judea region are widely used in traditional medicine. This phytogeographic zone stands out in its climatic conditions and biodiversity. Consequently, both endemic and widely distributed Mediterranean plants growing in the area have unique chemotypes characterized by accumulation of relatively high levels of phytosteroids. Our comprehensive analysis revealed that many of the plants growing in the Judea region may hold a geroprotective potential. With this in mind, we undertook a wide screen of dozens of candidate herbal extracts for their cell protective, wound-healing, anti-inflammatory, and anti-cancer activities. The results obtained thus far have clearly shown that the extracts tested (1) protect normal human fibroblasts from genotoxic stress (prevent DNA double-strand beaks, increase cell survival and reduce the number of cells undergoing cellular senescence), (2) decrease secretion of pro-inflammatory cytokines, (3) promote wound healing, and (4) exert more pronounced cytotoxicity toward cancer cells.
生长在朱迪亚地区的植物被广泛应用于传统医学。这个植物地理区以其独特的气候条件和生物多样性而著称。因此，该地区生长的地方性和广泛分布的地中海植物都具有独特的化学型，其特征是积累相对较高水平的植物甾醇。我们的综合分析表明，生长在朱迪亚地区的许多植物可能具有抗衰老的潜力。考虑到这一点，我们对数十种候选草药提取物进行了广泛的筛选，以研究它们的细胞保护、伤口愈合、抗炎和抗癌活性。迄今为止所获得的结果清楚地表明，测试的提取物（1）可保护正常人类成纤维细胞免受遗传毒性应激（防止 DNA 双链断裂，增加细胞存活率并减少发生细胞衰老的细胞数量），（2）减少促炎细胞因子的分泌，（3）促进伤口愈合，以及（4）对癌细胞表现出更明显的细胞毒性。
