口腔链球菌属交叉反应性多糖抗原（a、d和h型）与单克隆抗体的免疫学研究。
Immunological study of cross-reactive polysaccharide antigens (types a, d, and h) of oral Streptococcus spp. with monoclonal antibodies.
作者信息
Ota F, Kato H, Fukui K
出版信息
Infect Immun. 1987 Jan;55(1):266-8. doi: 10.1128/iai.55.1.266-268.1987.
Abstract
Two monoclonal antibodies against the cross-reactive antigens of S. cricetus (type a) and S. sobrinus (type d) were isolated. Galactose and especially melibiose inhibited the precipitin reaction markedly. Inhibition by melibiose was over 200-fold stronger than that by galactose. This may indicate that galactose-alpha 1, 6-glucose is the predominant antigenic determinant of this cross-reactive antigen. This antigen was also found in S. sobrinus type h strains, but no antigen was found in one type d strain (OMZ176).
摘要
分离出了两种针对仓鼠链球菌（a型）和远缘链球菌（d型）交叉反应抗原的单克隆抗体。半乳糖尤其是蜜二糖显著抑制沉淀反应。蜜二糖的抑制作用比半乳糖强200多倍。这可能表明α-1,6-半乳糖葡萄糖是这种交叉反应抗原的主要抗原决定簇。在远缘链球菌h型菌株中也发现了这种抗原，但在一株d型菌株（OMZ176）中未发现抗原。
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