玻璃体内白细胞介素-1β和白细胞介素-10水平升高在增殖性糖尿病视网膜病变中的作用。
Roles of elevated intravitreal IL-1β and IL-10 levels in proliferative diabetic retinopathy.
作者信息
Mao Chunjie, Yan Hua
机构信息
Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China.
出版信息
Indian J Ophthalmol. 2014 Jun;62(6):699-701. doi: 10.4103/0301-4738.136220.
Abstract
PURPOSE
To determine the roles of interleukin (IL)-1β and IL-10 in the vitreous of proliferative diabetic retinopathy (PDR).
MATERIALS AND METHODS
Vitreous samples were obtained from 26 eyes of 26 patients with PDR and from eight eyes of eight cases without PDR. The IL-1β and IL-10 concentration in the vitreous was measured by using an enzyme-linked immunosorbent assay (ELISA).
RESULTS
Levels of IL-1β and IL-10 in vitreous were higher in PDR patients compared with control group. And there was significantly negative correlation between IL-1β and IL-10 in control group (r = -0.795; P = 0.032), whereas there was no significant correlation in PDR group (r = 0.176; P = 0.391).
CONCLUSION
Levels of IL-1β and IL-10 were upregulated in vitreous of PDR patients, and these two cytokines play roles in regulating the development and progression of PDR.
摘要
目的
确定白细胞介素（IL）-1β和IL-10在增殖性糖尿病视网膜病变（PDR）玻璃体中的作用。
材料与方法
从26例PDR患者的26只眼中以及8例非PDR患者的8只眼中获取玻璃体样本。采用酶联免疫吸附测定（ELISA）法测量玻璃体中IL-1β和IL-10的浓度。
结果
与对照组相比，PDR患者玻璃体中IL-1β和IL-10水平更高。对照组中IL-1β与IL-10之间存在显著负相关（r = -0.795；P = 0.032），而PDR组中无显著相关性（r = 0.176；P = 0.391）。
结论
PDR患者玻璃体中IL-1β和IL-10水平上调，这两种细胞因子在调节PDR的发生发展中起作用。
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