金属纳米颗粒增强癌症放射治疗中的放射敏感性。
Enhancement of radiosensitization by metal-based nanoparticles in cancer radiation therapy.
机构信息
1 Department of Oncology, Zhongda Hospital of Southeast University, Nanjing 210009, China ; 2 Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China.
出版信息
Cancer Biol Med. 2014 Jun;11(2):86-91. doi: 10.7497/j.issn.2095-3941.2014.02.003.
Abstract
Radiation therapy performs an important function in cancer treatment. However, resistance of tumor cells to radiation therapy still remains a serious concern, so the study of radiosensitizers has emerged as a persistent hotspot in radiation oncology. Along with the rapid advancement of nanotechnology in recent years, the potential value of nanoparticles as novel radiosensitizers has been discovered. This review summarizes the latest experimental findings both in vitro and in vivo and attempts to highlight the underlying mechanisms of response in nanoparticle radiosensitization.
摘要
放射治疗在癌症治疗中发挥着重要作用。然而，肿瘤细胞对放射治疗的抵抗仍然是一个严重的问题，因此，放射增敏剂的研究成为放射肿瘤学领域的一个持续热点。近年来，随着纳米技术的快速发展，纳米粒子作为新型放射增敏剂的潜在价值已经被发现。本文综述了体外和体内的最新实验结果，并试图强调纳米粒子放射增敏作用的潜在机制。
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