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人体经颅电流刺激的方法学维度

Methodological dimensions of transcranial brain stimulation with the electrical current in human.

作者信息

Rostami Maryam, Golesorkhi Mehrshad, Ekhtiari Hamed

机构信息

Translational Neuroscience Program, Institute for Cognitive Science Studies, Tehran, Iran ; Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.

Translational Neuroscience Program, Institute for Cognitive Science Studies, Tehran, Iran ; Neuroimaging and Analysis Group, Research Center for Molecular and Cellular Imaging, Tehran University for Medical Sciences, Tehran, Iran ; Department of Computer Science, School of Mathematics, Statistics and Computer Science, University of Tehran, Tehran, Iran.

出版信息

Basic Clin Neurosci. 2013 Summer;4(3):190-208.

PMID:25337348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4202570/
Abstract

Transcranial current stimulation (TCS) is a neuromodulation method in which the patient is exposed to a mild electric current (direct or alternating) at 1-2 mA, resulting in an increase or a decrease in the brain excitability. This modification in neural activities can be used as a method for functional human brain mapping with causal inferences. This method might also facilitate the treatments of many neuropsychiatric disorders based on its inexpensive, simple, safe, noninvasive, painless, semi-focal excitatory and inhibitory effects. Given this, a comparison amongst different brain stimulation modalities has been made to determine the potential advantages of the TCS method. In addition, considerable methodological details on using TCS in basic and clinical neuroscience studies in human subjects have been introduced. Technical characteristics of TCS devices and their related accessories with regard to safety concerns have also been well articulated. Finally, some TCS application opportunities have been emphasized, including its potential use in the near future.

摘要

经颅电流刺激（TCS）是一种神经调节方法，在此过程中，患者会暴露于1-2毫安的微弱电流（直流电或交流电）下，从而导致大脑兴奋性增加或降低。这种神经活动的改变可作为一种用于进行具有因果推断的功能性人脑图谱绘制的方法。基于其价格低廉、操作简单、安全、无创、无痛、半聚焦性兴奋和抑制作用，该方法还可能有助于许多神经精神疾病的治疗。鉴于此，已对不同的脑刺激方式进行了比较，以确定TCS方法的潜在优势。此外，还介绍了在人体基础和临床神经科学研究中使用TCS的大量方法学细节。TCS设备及其相关附件在安全方面的技术特性也得到了很好的阐述。最后，强调了一些TCS的应用机会，包括其在不久的将来的潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bf1/4202570/077a669eb807/BCN-4-190-g009.jpg
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Front Syst Neurosci. 2012 May 25;6:39. doi: 10.3389/fnsys.2012.00039. eCollection 2012.
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A pilot study of the tolerability and effects of high-definition transcranial direct current stimulation (HD-tDCS) on pain perception.
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Neurobiological After-Effects of Low Intensity Transcranial Electric Stimulation of the Human Nervous System: From Basic Mechanisms to Metaplasticity.低强度经颅电刺激人类神经系统的神经生物学后效应：从基本机制到可塑性变化
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