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抑郁症的诊断和抗抑郁药物的处方是否因地区而异?使用大型初级保健数据集对种族密度关联进行分析。

Does depression diagnosis and antidepressant prescribing vary by location? Analysis of ethnic density associations using a large primary-care dataset.

作者信息

Schofield P, Das-Munshi J, Mathur R, Congdon P, Hull S

机构信息

Division of Health & Social Care Research,Faculty of Life Sciences & Medicine,King's College London,Addison House,Guy's Campus,London,UK.

Institute of Psychiatry, Psychology & Neuroscience,King's College London,UK.

出版信息

Psychol Med. 2016 Apr;46(6):1321-9. doi: 10.1017/S0033291715002913. Epub 2016 Feb 16.

DOI:10.1017/S0033291715002913
PMID:26879871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4828938/
Abstract

BACKGROUND

Studies have linked ethnic differences in depression rates with neighbourhood ethnic density although results have not been conclusive. We looked at this using a novel approach analysing whole population data covering just over one million GP patients in four London boroughs.

METHOD

Using a dataset of GP records for all patients registered in Lambeth, Hackney, Tower Hamlets and Newham in 2013 we investigated new diagnoses of depression and antidepressant use for: Indian, Pakistani, Bangladeshi, black Caribbean and black African patients. Neighbourhood effects were assessed independently of GP practice using a cross-classified multilevel model.

RESULTS

Black and minority ethnic groups are up to four times less likely to be newly diagnosed with depression or prescribed antidepressants compared to white British patients. We found an inverse relationship between neighbourhood ethnic density and new depression diagnosis for some groups, where an increase of 10% own-ethnic density was associated with a statistically significant (p < 0.05) reduced odds of depression for Pakistani [odds ratio (OR) 0.81, 95% confidence interval (CI) 0.70-0.93], Indian (OR 0.88, CI 0.81-0.95), African (OR 0.88, CI 0.78-0.99) and Bangladeshi (OR 0.94, CI 0.90-0.99) patients. Black Caribbean patients, however, showed the opposite effect (OR 1.26, CI 1.09-1.46). The results for antidepressant use were very similar although the corresponding effect for black Caribbeans was no longer statistically significant (p = 0.07).

CONCLUSION

New depression diagnosis and antidepressant use was shown to be less likely in areas of higher own-ethnic density for some, but not all, ethnic groups.

摘要

背景

尽管研究结果尚无定论,但已有研究将抑郁症发病率的种族差异与邻里种族密度联系起来。我们采用一种新颖的方法对此进行了研究,分析了伦敦四个行政区超过100万全科医生患者的全人群数据。

方法

利用2013年在兰贝斯、哈克尼、陶尔哈姆莱茨和纽汉登记的所有患者的全科医生记录数据集,我们调查了印度、巴基斯坦、孟加拉、加勒比黑人及非洲黑人患者的抑郁症新诊断情况和抗抑郁药使用情况。使用交叉分类多水平模型独立于全科医生诊所评估邻里效应。

结果

与英国白人患者相比,黑人和少数族裔群体新诊断为抑郁症或开具抗抑郁药的可能性低至四倍。我们发现,对于某些群体,邻里种族密度与新的抑郁症诊断之间存在反比关系,即自有种族密度每增加10%,巴基斯坦人[比值比(OR)0.81,95%置信区间(CI)0.70 - 0.93]、印度人(OR 0.88,CI 0.81 - 0.95)、非洲人(OR 0.88,CI 0.78 - 0.99)和孟加拉人(OR 0.94,CI 0.90 - 0.99)患抑郁症的几率在统计学上显著降低(p < 0.05)。然而,加勒比黑人患者表现出相反的效果(OR 1.26,CI 1.09 - 1.46)。抗抑郁药使用情况的结果非常相似,尽管加勒比黑人的相应效果不再具有统计学意义(p = 0.07)。

结论

对于部分而非所有种族群体,自有种族密度较高的地区新的抑郁症诊断和抗抑郁药使用的可能性较低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecf0/4828938/020f98c5fb13/S0033291715002913_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecf0/4828938/0bdced056a7a/S0033291715002913_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecf0/4828938/020f98c5fb13/S0033291715002913_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecf0/4828938/0bdced056a7a/S0033291715002913_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecf0/4828938/020f98c5fb13/S0033291715002913_fig2.jpg

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