Guisbiers G, Wang Q, Khachatryan E, Mimun L C, Mendoza-Cruz R, Larese-Casanova P, Webster T J, Nash K L
Department of Physics and Astronomy, The University of Texas at San Antonio, San Antonio, TX.
Department of Bioengineering.
Int J Nanomedicine. 2016 Aug 8;11:3731-6. doi: 10.2147/IJN.S106289. eCollection 2016.
Nosocomial diseases are mainly caused by two common pathogens, Escherichia coli and Staphylococcus aureus, which are becoming more and more resistant to conventional antibiotics. Therefore, it is becoming increasingly necessary to find other alternative treatments than commonly utilized drugs. A promising strategy is to use nanomaterials such as selenium nanoparticles. However, the ability to produce nanoparticles free of any contamination is very challenging, especially for nano-medical applications. This paper reports the successful synthesis of pure selenium nanoparticles by laser ablation in water and determines the minimal concentration required for ~50% inhibition of either E. coli or S. aureus after 24 hours to be at least ~50 ppm. Total inhibition of E. coli and S. aureus is expected to occur at 107±12 and 79±4 ppm, respectively. In this manner, this study reports for the first time an easy synthesis process for creating pure selenium to inhibit bacterial growth.
医院感染主要由两种常见病原体引起，即大肠杆菌和金黄色葡萄球菌，它们对传统抗生素的耐药性越来越强。因此，寻找不同于常用药物的其他替代治疗方法变得越来越必要。一种有前景的策略是使用纳米材料，如硒纳米颗粒。然而，生产不含任何污染物的纳米颗粒的能力非常具有挑战性，尤其是对于纳米医学应用。本文报道了通过水中激光烧蚀成功合成纯硒纳米颗粒，并确定在24小时后对大肠杆菌或金黄色葡萄球菌约50%抑制所需的最低浓度至少为约50 ppm。预计对大肠杆菌和金黄色葡萄球菌的完全抑制分别发生在107±12 ppm和79±4 ppm。通过这种方式，本研究首次报道了一种简单的合成纯硒以抑制细菌生长的过程。
