一种感染机会致病菌深红沙雷氏菌的烈性噬菌体的首个全基因组序列
First complete genome sequence of a virulent bacteriophage infecting the opportunistic pathogen Serratia rubidaea.
作者信息
Xing Shaozhen, Ma Taping, Zhang Xianglilan, Huang Yong, Mi Zhiqiang, Sun Qiang, An Xiaoping, Fan Hang, Wu Shuhui, Wei Lin, Tong Yigang
机构信息
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, People's Republic of China.
Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, 050017, People's Republic of China.
出版信息
Arch Virol. 2017 Jul;162(7):2021-2028. doi: 10.1007/s00705-017-3300-x. Epub 2017 Mar 6.
A Serratia rubidaea phage, vB_Sru IME250, was isolated from hospital sewage. The morphology suggested that phage vB_Sru IME250 should be classified as a member of the family Myoviridae. High-throughput sequencing revealed that the phage genome has 154,938 nucleotides and consists of 193 coding DNA sequences, 90 of which have putative functions. The genome of vB_Sru IME250 is a linear, double-stranded DNA with an average GC content of 40.04%. The phage has a relatively high similarity to Klebsiella phage 0507-KN2-1, with a genome coverage of 84%.
从医院污水中分离出一株粘质沙雷氏菌噬菌体vB_Sru IME250。其形态表明噬菌体vB_Sru IME250应归类为肌尾噬菌体科的成员。高通量测序显示该噬菌体基因组有154,938个核苷酸，由193个编码DNA序列组成，其中90个具有推定功能。vB_Sru IME250的基因组是线性双链DNA，平均GC含量为40.04%。该噬菌体与肺炎克雷伯菌噬菌体0507-KN2-1有较高的相似性，基因组覆盖率为84%。
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