Department of Nutrition, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan, R.O.C.
Medical Education Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan, R.O.C.
Int J Mol Med. 2018 Apr;41(4):2420-2428. doi: 10.3892/ijmm.2018.3380. Epub 2018 Jan 11.
Ginger (Zingiber officinale Roscoe) is a popular Chinese herbal medicine, which is considered to warm the stomach and dispel cold in traditional Chinese medicine. Ginger is widely used to treat stomach disorders, and it has been reported to exhibit antithrombotic activity via the inhibition of platelet aggregation and thromboxane B2 production in vitro. Cardiovascular disease is associated with the aberrant functioning of the heart and circulatory system; the relatively narrow vessels of the circulation are commonly affected and blocked by atherosclerosis, which may result in angina or heart attack. Numerous drugs and medicines are used to treat myocardial infarction; however, they are often associated with numerous side effects. Therefore, it is important to identify substitutive drugs with no unbearable side effects. In the present study, the relaxant effects of ginger crude extract (GCE) were determined on porcine coronary arteries. The DPPH radical scavenging assay, lucigenin‑enhanced chemiluminescence assay and western blot analysis were used to individually detect antioxidant assay of ginger extraction or superoxide anion produced by endothelial cells and molecular signaling. The results indicated that GCE induced relaxation of porcine coronary arteries in an endothelium‑dependent manner. GCE increased vasoprotection via the suppression of nitric oxide synthase and cyclooxygenase. In addition, GCE possessed antioxidant ability, as determined using 1,1‑diphenyl‑2‑picrylhydrazyl and lucigenin‑enhanced chemiluminescence assays. Taken together, the present study demonstrated that GCE exerts marked vasoprotective effects and free radical‑scavenging activities in porcine coronary arteries.
生姜（Zingiber officinale Roscoe）是一种常用的中草药，在中医中被认为具有暖胃散寒的功效。生姜被广泛用于治疗胃部疾病，据报道，它具有抗血栓活性，能够抑制血小板聚集和血栓素 B2 的产生。心血管疾病与心脏和循环系统的异常功能有关；循环系统相对较窄的血管常受到动脉粥样硬化的影响和阻塞，这可能导致心绞痛或心脏病发作。有许多药物用于治疗心肌梗死；然而，它们通常伴随着许多副作用。因此，寻找没有难以忍受的副作用的替代药物非常重要。在本研究中，研究人员测定了生姜粗提取物（GCE）对猪冠状动脉的舒张作用。DPPH 自由基清除试验、荧光素增强化学发光试验和 Western blot 分析分别用于检测生姜提取物的抗氧化试验或内皮细胞产生的超氧阴离子和分子信号。结果表明，GCE 以依赖内皮的方式诱导猪冠状动脉舒张。GCE 通过抑制一氧化氮合酶和环氧化酶增加血管保护作用。此外，GCE 还具有抗氧化能力，这可以通过 1,1-二苯基-2-苦基肼和荧光素增强化学发光试验来确定。综上所述，本研究表明，GCE 在猪冠状动脉中具有显著的血管保护作用和自由基清除活性。
