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与宫颈癌相关的人乳头瘤病毒33型的基因组结构和核苷酸序列。

Genome organization and nucleotide sequence of human papillomavirus type 33, which is associated with cervical cancer.

作者信息

Cole S T, Streeck R E

出版信息

J Virol. 1986 Jun;58(3):991-5. doi: 10.1128/JVI.58.3.991-995.1986.

DOI:10.1128/JVI.58.3.991-995.1986
PMID:3009902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC253014/
Abstract

The 7,909-nucleotide sequence of human papillomavirus type 33, which is associated with cervical cancer, has been determined and used to deduce the corresponding genome arrangement. Extensive sequence homologies and other genetic features are shared with the related oncogenic virus, human papillomavirus type 16, especially in the major reading frames. A surprising difference was found in the noncoding region of human papillomavirus type 33 as, unlike all other sequenced papillomaviruses, it contains a perfect 78-base pair tandem repeat.

摘要

与宫颈癌相关的人乳头瘤病毒16型的7909个核苷酸序列已被确定,并用于推导相应的基因组排列。它与相关致癌病毒人乳头瘤病毒16型具有广泛的序列同源性和其他遗传特征,尤其是在主要阅读框中。在人乳头瘤病毒16型的非编码区发现了一个惊人的差异,与所有其他已测序的乳头瘤病毒不同,它包含一个完美的78个碱基对的串联重复序列。

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本文引用的文献

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A new computer method for the storage and manipulation of DNA gel reading data.一种用于存储和处理DNA凝胶读数数据的新型计算机方法。
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