Department of Electrical and Computer Engineering , University of California San Diego La Jolla , California 92093 , United States.
Department of Neurology , Massachusetts General Hospital , Boston , Massachusetts 02114 , United States.
Nano Lett. 2019 Sep 11;19(9):6244-6254. doi: 10.1021/acs.nanolett.9b02296. Epub 2019 Aug 8.
The enhanced electrochemical activity of nanostructured materials is readily exploited in energy devices, but their utility in scalable and human-compatible implantable neural interfaces can significantly advance the performance of clinical and research electrodes. We utilize low-temperature selective dealloying to develop scalable and biocompatible one-dimensional platinum nanorod (PtNR) arrays that exhibit superb electrochemical properties at various length scales, stability, and biocompatibility for high performance neurotechnologies. PtNR arrays record brain activity with cellular resolution from the cortical surfaces in birds and nonhuman primates. Significantly, strong modulation of surface recorded single unit activity by auditory stimuli is demonstrated in European Starling birds as well as the modulation of local field potentials in the visual cortex by light stimuli in a nonhuman primate and responses to electrical stimulation in mice. PtNRs record behaviorally and physiologically relevant neuronal dynamics from the surface of the brain with high spatiotemporal resolution, which paves the way for less invasive brain-machine interfaces.
纳米结构材料增强的电化学活性在能源设备中得到了广泛应用，但将其应用于可扩展和与人兼容的植入式神经接口中，可以显著提高临床和研究电极的性能。我们利用低温选择性脱合金技术开发了可扩展和生物兼容的一维铂纳米棒 (PtNR) 阵列，该阵列在各种长度尺度上表现出优异的电化学性能、稳定性和生物相容性，适用于高性能神经技术。PtNR 阵列可从鸟类和非人类灵长类动物的皮质表面以细胞分辨率记录大脑活动。值得注意的是，在欧洲椋鸟中证明了表面记录的单个单元活动可以被听觉刺激强烈调制，并且在非人类灵长类动物中可以用光刺激调制视觉皮层中的局部场电位，以及对小鼠电刺激的反应。PtNR 以高时空分辨率从大脑表面记录与行为和生理相关的神经元动力学，为侵入性较小的脑机接口铺平了道路。
