Golnaraghi Ghomi Ahmad Reza, Mohammadi-Khanaposhti Mohammad, Vahidi Hossein, Kobarfard Farzad, Ameri Shah Reza Mahdieh, Barabadi Hamed
Fouman Faculty of Engineering, College of Engineering, University of Tehran, Fouman, Iran.
Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Pharm Res. 2019 Fall;18(4):2101-2110. doi: 10.22037/ijpr.2019.112382.13722.
Biological synthesis of nanoparticles (NPs) has gained extensive attention during recent years by using various biological resources such as plant extracts and microorganisms as reducing and stabilizing agents. The objective of the present study was to biosynthesize zirconium NPs using species as a reliable and eco-friendly protocol for the first time. The synthesized NPs were characterized using Scanning Electron Microscope (SEM), Atomic Force Microscope (AFM), Dynamic Light Scattering (DLS), Energy Dispersive X-ray (EDX), and Fourier Transform Infrared (FT-IR). The results showed that three species were able to synthesize zirconium NPs extracellularly with spherical morphology below 100 nm. Moreover, the preliminary antibacterial activity of zirconium NPs represented considerable antibacterial potential against Gram-negative bacteria. Overall, the current study demonstrated a novel bio-based approach for preparation of zirconium NPs. Further studies are required to expend this laboratory-based investigation to an industrial scale owing to their superiorities over traditional physicochemical methods such as cost-effectiveness and eco-friendliness.
近年来，利用植物提取物和微生物等各种生物资源作为还原剂和稳定剂来生物合成纳米颗粒（NPs）受到了广泛关注。本研究的目的是首次使用[具体物种]作为可靠且环保的方案来生物合成锆纳米颗粒。使用扫描电子显微镜（SEM）、原子力显微镜（AFM）、动态光散射（DLS）、能量色散X射线（EDX）和傅里叶变换红外光谱（FT-IR）对合成的纳米颗粒进行了表征。结果表明，三种[具体物种]能够在细胞外合成形态为球形、尺寸低于100 nm的锆纳米颗粒。此外，锆纳米颗粒的初步抗菌活性对革兰氏阴性菌显示出相当大的抗菌潜力。总体而言，当前研究展示了一种制备锆纳米颗粒的新型生物基方法。由于其相较于传统物理化学方法具有成本效益和生态友好等优势，需要进一步开展研究将这种基于实验室的研究扩展到工业规模。
