Ding Chizhu, Chen Xiang, Kang Qinshu, Yan Xianghua
State Key Laboratory of Agricultural Microbiology, College of Science, Huazhong Agricultural University, Wuhan, China.
State Key Laboratory of Agricultural Microbiology, College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, China.
Front Bioeng Biotechnol. 2020 Jul 22;8:823. doi: 10.3389/fbioe.2020.00823. eCollection 2020.
The organ-on-a-chip (OOC) technology has been utilized in a lot of biomedical fields such as fundamental physiological and pharmacological researches. Various materials have been introduced in OOC and can be broadly classified into inorganic, organic, and hybrid materials. Although PDMS continues to be the preferred material for laboratory research, materials for OOC are constantly evolving and progressing, and have promoted the development of OOC. This mini review provides a summary of the various type of materials for OOC systems, focusing on the progress of materials and related fabrication technologies within the last 5 years. The advantages and drawbacks of these materials in particular applications are discussed. In addition, future perspectives and challenges are also discussed.
芯片器官（OOC）技术已被应用于许多生物医学领域，如基础生理学和药理学研究。各种材料已被引入到芯片器官中，大致可分为无机材料、有机材料和混合材料。尽管聚二甲基硅氧烷（PDMS）仍然是实验室研究的首选材料，但芯片器官的材料也在不断发展和进步，并推动了芯片器官的发展。本综述总结了用于芯片器官系统的各种材料类型，重点介绍了过去5年中材料及相关制造技术的进展。讨论了这些材料在特定应用中的优缺点。此外，还讨论了未来的前景和挑战。
