Ghafouri-Fard Soudeh, Niazi Vahid, Taheri Mohammad
Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Noncoding RNA Res. 2020 Dec 19;6(1):8-14. doi: 10.1016/j.ncrna.2020.12.002. eCollection 2021 Mar.
Non-coding RNAs (ncRNAs) have diverse roles in the differentiation of hematopoietic cells. Among these transcripts, long ncRNAs (lncRNAs) and microRNAs (miRNAs) have especial contribution in this regard particularly by affecting levels of transcription factors that define differentiation of each linage. miR-222, miR-10a, miR-126, miR-106, miR-10b, miR-17, miR-20, miR-146, miR-155, miR-223, miR-221, miR-92, miR-150, miR-126 and miR-142 are among miRNAs that partake in the differentiation of hematopoietic stem cells. Meanwhile, this process is controlled by a number of lncRNAs such as PU.1-AS, AlncRNA-EC7, EGO, HOTAIRM1, Fas-AS1, LincRNA-EPS and lncRNA-CSR. Manipulation of expression of these transcripts has functional significance in the treatment of cancers and in cell therapy. In this paper, we have provided a brief summary of the role of miRNAs and lncRNAs in the regulation of hematopoietic stem cells.
非编码RNA（ncRNAs）在造血细胞分化中具有多种作用。在这些转录本中，长链非编码RNA（lncRNAs）和微小RNA（miRNAs）在这方面有特殊贡献，特别是通过影响定义每个谱系分化的转录因子水平。miR-222、miR-10a、miR-126、miR-106、miR-10b、miR-17、miR-20、miR-146、miR-155、miR-223、miR-221、miR-92、miR-150、miR-126和miR-142等miRNAs参与造血干细胞的分化。同时，这一过程受多种lncRNAs调控，如PU.1-AS、AlncRNA-EC7、EGO、HOTAIRM1、Fas-AS1、LincRNA-EPS和lncRNA-CSR。操纵这些转录本的表达在癌症治疗和细胞治疗中具有功能意义。在本文中，我们简要总结了miRNAs和lncRNAs在造血干细胞调控中的作用。
