Department of Circulation and Medical Imaging, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.
Department of Radiology and Nuclear Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Sci Rep. 2021 Jan 22;11(1):2085. doi: 10.1038/s41598-021-81272-x.
T-weighted (TW) MRI provides high spatial resolution and tissue-specific contrast, but it is predominantly used for qualitative evaluation of prostate anatomy and anomalies. This retrospective multicenter study evaluated the potential of TW image-derived textural features for quantitative assessment of peripheral zone prostate cancer (PCa) aggressiveness. A standardized preoperative multiparametric MRI was performed on 87 PCa patients across 6 institutions. TW intensity and apparent diffusion coefficient (ADC) histogram, and TW textural features were computed from tumor volumes annotated based on whole-mount histology. Spearman correlations were used to evaluate association between textural features and PCa grade groups (i.e. 1-5). Feature utility in differentiating and classifying low-(grade group 1) vs. intermediate/high-(grade group ≥ 2) aggressive cancers was evaluated using Mann-Whitney U-tests, and a support vector machine classifier employing "hold-one-institution-out" cross-validation scheme, respectively. Textural features indicating image homogeneity and disorder/complexity correlated significantly (p < 0.05) with PCa grade groups. In the intermediate/high-aggressive cancers, textural homogeneity and disorder/complexity were significantly lower and higher, respectively, compared to the low-aggressive cancers. The mean classification accuracy across the centers was highest for the combined ADC and TW intensity-textural features (84%) compared to ADC histogram (75%), TW histogram (72%), TW textural (72%) features alone or TW histogram and texture (77%), TW and ADC histogram (79%) combined. Texture analysis of TW images provides quantitative information or features that are associated with peripheral zone PCa aggressiveness and can augment their classification.
T 加权（TW）MRI 提供了高空间分辨率和组织特异性对比，但主要用于前列腺解剖结构和异常的定性评估。本回顾性多中心研究评估了 TW 图像衍生纹理特征在定量评估外周带前列腺癌（PCa）侵袭性方面的潜力。在 6 家机构对 87 例 PCa 患者进行了标准化的术前多参数 MRI 检查。从基于全组织学的肿瘤体积标注中计算了 TW 强度和表观扩散系数（ADC）直方图以及 TW 纹理特征。使用 Spearman 相关分析评估纹理特征与 PCa 分级组（即 1-5 级）之间的相关性。使用 Mann-Whitney U 检验评估了纹理特征在区分和分类低（分级组 1）与中/高（分级组≥2）侵袭性癌症方面的作用，并使用支持向量机分类器，采用“一机构外留一机构”交叉验证方案。指示图像均匀性和无序/复杂性的纹理特征与 PCa 分级组显著相关（p<0.05）。在中/高侵袭性癌症中，与低侵袭性癌症相比，纹理均匀性和无序/复杂性分别显著降低和升高。跨中心的平均分类准确率以 ADC 和 TW 强度纹理特征的组合最高（84%），其次是 ADC 直方图（75%）、TW 直方图（72%）、TW 纹理（72%）特征单独或 TW 直方图和纹理（77%）、TW 和 ADC 直方图（79%）组合。TW 图像的纹理分析提供了与外周带 PCa 侵袭性相关的定量信息或特征，可增强其分类。
