Eriksen C A, Sadek S A, Cranford C, Sutton D, Kennedy N, Cuschieri A
Department of Surgery, Ninewells Hospital and Medical School, Dundee.
Gut. 1988 Apr;29(4):448-52. doi: 10.1136/gut.29.4.448.
Patients with reflux oesophagitis have a diminished capacity for distal oesophageal clearance. This is considered to be secondary to acid reflux damage to the oesophageal wall. We have postulated that the observed oesophageal dysmotility is a primary phenomenon. Using 24 hour oesophageal pH monitoring and the solid bolus oesophageal egg transit test, we evaluated the oesophageal transit of 55 patients, with symptomatic reflux oesophagitis, and 16 healthy volunteers. The transit for the entire oesophagus was significantly prolonged in the patient group. This delay was evident in all three segments of the oesophagus. Amongst the patients, there was significant correlation between the oesophageal transit time and the number of prolonged reflux events. No correlation was found, however, between symptom score or severity of endoscopic oesophagitis and transit time. These results would indicate that the oesophageal dysmotility is an integral part of gastrooesophageal reflux disease, and is more of a cause than an effect.
反流性食管炎患者远端食管清除能力减弱。这被认为是食管壁酸反流损伤的继发结果。我们推测观察到的食管运动障碍是一种原发性现象。通过24小时食管pH监测和固体团块食管卵转运试验，我们评估了55例有症状反流性食管炎患者和16名健康志愿者的食管转运情况。患者组整个食管的转运时间显著延长。这种延迟在食管的所有三个节段都很明显。在患者中，食管转运时间与长时间反流事件的数量之间存在显著相关性。然而，症状评分或内镜下食管炎的严重程度与转运时间之间未发现相关性。这些结果表明食管运动障碍是胃食管反流病的一个组成部分，且更多是病因而非结果。
