Huang Zhimao, Zhang Dawei, Gu Qinwei, Miao Jiru, Cen Xiao, Golodok Robert Petrovich, Savich Vadim Victorovich, Ilyushchenko Alexander Phyodorovich, Zhou Zhansong, Wang Rong
Zhejiang International Scientific and Technological Cooperative Base of Biomedical Materials and Technology, Zhejiang Engineering Research Center for Biomedical Materials, Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences Ningbo 315300 China
Department of Urology, The Southwest Hospital, Army Medical University No. 30 Gaotanyan Street, Shapingba District Chongqing 400038 China
RSC Adv. 2022 May 25;12(25):15685-15693. doi: 10.1039/d2ra01675c. eCollection 2022 May 23.
Catheter-associated urinary tract infections (CAUTIs) draw great concern due to increased demand for urinary catheters in hospitalization. Encrustation caused by urinary pathogens, especially , results in blocking of the catheter lumen and further infections. In this study, a facile and low-cost surface modification strategy of urinary catheters was developed using one-step coordination of tannic acid (TA) and copper ions. The copper content of the coating could be manipulated by the number of TA-Cu (TC) layers, and the coating released copper in a pH-responsive manner. The coating exhibited high antibacterial efficiency (killed >99% of planktonic bacteria, and reduced biofilm coverage to <1% after 24 h) due to the synergistic antimicrobial effect of TA and copper ions. study with a rabbit model indicated that with two TC layers, the coated catheter could effectively inhibit bacterial growth in urine and colonization on the surface, and reduce encrustation formation. In addition, the TC-coated catheter exhibited better tissue compatibility compared to the unmodified catheter, probably due to the antibacterial performance of the coating. Such a straightforward coating strategy with good and antibacterial properties and biocompatibility holds great promise for combating CAUTIs in clinical practice.
由于住院期间对导尿管的需求增加，导尿管相关尿路感染（CAUTIs）引起了极大关注。尿路病原体引起的结壳，尤其是导致导尿管内腔堵塞并引发进一步感染。在本研究中，利用单宁酸（TA）与铜离子的一步配位反应，开发了一种简便且低成本的导尿管表面改性策略。涂层中的铜含量可通过TA-Cu（TC）层数进行调控，且涂层以pH响应方式释放铜。由于TA和铜离子的协同抗菌作用，该涂层表现出高抗菌效率（杀死>99%的浮游细菌，24小时后生物膜覆盖率降低至<1%）。一项兔模型研究表明，带有两层TC的涂层导尿管可有效抑制尿液中的细菌生长以及表面的细菌定植，并减少结壳形成。此外，与未改性的导尿管相比，TC涂层导尿管表现出更好的组织相容性，这可能归因于涂层的抗菌性能。这种具有良好抗菌性能和生物相容性的直接涂层策略在临床实践中对抗CAUTIs具有巨大潜力。
