Wang Yiran, Wan Ting, Liu Luze, Xue Yuyuan, Chen Xinyao, Savini Giacomo, Schiano-Lomoriello Domenico, Zhou Xingtao, Yu Jinjin, Huang Jinhai
Eye Institute and Department of Ophthalmology, Institute for Medical and Engineering Innovation, Eye & ENT Hospital, Fudan University; NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, No.19 Baoqing Road, Xuhui District, Shanghai, 200031, China.
Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Eye Vis (Lond). 2023 Feb 25;10(1):13. doi: 10.1186/s40662-023-00330-9.
To assess agreement of measurements between a new optical low coherence reflectometry (OLCR) biometer (SW-9000, Suoer, Tianjin, China) and a spectral-domain optical coherence tomographer (SD-OCT)/Placido topographer (MS-39, CSO, Florence, Italy) in healthy subjects.
A total of 66 right eyes from 66 healthy subjects were enrolled in this prospective study. Three consecutive measurements were randomly obtained with both devices by the same experienced operator to assess agreement. Bland-Altman plots and 95% limits of agreement (LoA) were used to verify the agreement between the devices. Results are presented as mean ± standard deviation (SD).
The SD-OCT/Placido tomographer showed high agreement with the OLCR biometer for all parameters included in this study. The mean differences of central corneal thickness (CCT), anterior chamber depth (ACD), aqueous depth (AQD), mean keratometry (Km) and corneal diameter (CD) were 2.21 ± 2.67 μm (P < 0.001), - 0.10 ± 0.03 mm (P < 0.001), - 0.10 ± 0.04 mm (P < 0.001), - 0.01 ± 0.22 D (P = 0.773) and 0.20 ± 0.16 mm (P < 0.001), respectively. This implies that the inter-device difference in Km was not statistically significant, while the differences in CCT, ACD, AQD, CD were statistically but not clinically significant. The 95% LoAs of CCT, ACD, AQD, Km and CD were - 3.01 to 7.44 μm, - 0.16 to - 0.05 mm, - 0.18 to - 0.03 mm, - 0.45 to 0.43 D, and - 0.12 to 0.51 mm, respectively.
For CCT, ACD, AQD, Km, and CD in healthy subjects, the new OLCR biometer has high agreement with the SD-OCT/Placido tomographer and can be used interchangeably due to the narrow range of 95% LoAs.
评估一种新型光学低相干反射仪（OLCR）生物测量仪（SW - 9000，中国天津索维）与光谱域光学相干断层扫描仪（SD - OCT）/普拉西多角膜地形图仪（MS - 39，意大利佛罗伦萨CSO）在健康受试者中测量结果的一致性。
本前瞻性研究纳入了66名健康受试者的66只右眼。由同一位经验丰富的操作人员使用这两种设备随机进行连续三次测量以评估一致性。采用布兰德 - 奥特曼图和95%一致性界限（LoA）来验证两种设备之间的一致性。结果以平均值±标准差（SD）表示。
SD - OCT/普拉西多角膜地形图仪与OLCR生物测量仪在本研究纳入的所有参数上均显示出高度一致性。中央角膜厚度（CCT）、前房深度（ACD）、房水深度（AQD）、平均角膜曲率（Km）和角膜直径（CD）的平均差异分别为2.21±2.67μm（P < 0.001）、 - 0.10±0.03mm（P < 0.001）、 - 0.10±0.04mm（P < 0.001）、 - 0.01±0.22D（P = 0.773）和0.20±0.16mm（P < 0.001）。这意味着Km的设备间差异无统计学意义，而CCT、ACD、AQD、CD的差异虽有统计学意义但无临床意义。CCT、ACD、AQD、Km和CD的95% LoA分别为 - 3.01至7.44μm、 - 0.16至 - 0.05mm、 - 0.18至 - 0.03mm、 - 0.45至0.43D和 - 0.12至0.51mm。
对于健康受试者的CCT、ACD、AQD、Km和CD，新型OLCR生物测量仪与SD - OCT/普拉西多角膜地形图仪具有高度一致性，且由于95% LoA范围较窄，可互换使用。
