Malik Maqsood Ahmad, AlHarbi Laila, Nabi Arshid, Alzahrani Khalid Ahmed, Narasimharao Katabathini, Kamli Majid Rasool
Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.
Department of Chemistry, University of Malaya, Kuala Lumpur 50603, Malaysia.
Pharmaceutics. 2023 Feb 14;15(2):642. doi: 10.3390/pharmaceutics15020642.
This article reports on incorporating magnetic nanoparticles into natural carbon frameworks derived from seeds and their synthesis via co-precipitation reactions for application in biomedicine. The magnetic Seeds (Magnetic NSS), a metal oxide-based bio-nanomaterial, has shown excellent water diaper presence due to the presence of a wide range of oxygenous hydroxyl and carboxyl groups. The physicochemical properties of the composites were characterized extensively using Fourier transform infrared spectroscopy (FTIR), powder-X-ray diffraction (XRD), scanning electron microscopy (SEM), elemental analysis, transmission electron microscopy (TEM), and vibrating-sample magnetometer. Furthermore, synthesized magnetic NSS showed antioxidant and antifungal activity. The antifungal susceptibility was further tested against with a MIC value of 3.125 µg/mL. Analysis of antioxidant defense enzymes was determined quantitatively; the results suggested that antioxidant enzyme activity increase with increased magnetic NSS concentration. Furthermore, biofilm inhibition assay from scanning electron microscopy results revealed that magnetic NSS at the concentration of 3.5 μg/mL has anti-biofilm properties and can disrupt membrane integrity.
本文报道了将磁性纳米颗粒掺入源自种子的天然碳框架中，并通过共沉淀反应进行合成，以应用于生物医学。磁性种子（Magnetic NSS）是一种基于金属氧化物的生物纳米材料，由于存在多种含氧的羟基和羧基，表现出优异的亲水性。使用傅里叶变换红外光谱（FTIR）、粉末X射线衍射（XRD）、扫描电子显微镜（SEM）、元素分析、透射电子显微镜（TEM）和振动样品磁强计对复合材料的物理化学性质进行了广泛表征。此外，合成的磁性NSS表现出抗氧化和抗真菌活性。进一步测试了其抗真菌药敏性，MIC值为3.125 µg/mL。对抗氧化防御酶进行了定量分析；结果表明，抗氧化酶活性随磁性NSS浓度的增加而增加。此外，扫描电子显微镜结果的生物膜抑制试验表明，浓度为3.5 μg/mL的磁性NSS具有抗生物膜特性，可破坏膜完整性。
