Heshmat Haleh, Kazemi Haleh, Hoorizad Ganjkar Maryam, Chaboki Farhad, Shokri Mahoor, Kharazifard Mohamad Javad
Dept. of Restorative Dentistry, Member of Dental Material Research Center, Islamic Azad University of Medical Sciences, Tehran, Iran.
Dept. of Restorative Dentistry, School of Dentistry, Islamic Azad University of Medical Sciences, Tehran, Iran.
J Dent (Shiraz). 2023 Dec 1;24(4):417-421. doi: 10.30476/dentjods.2023.95663.1883. eCollection 2023 Dec.
The prevalence of non-carious dentin lesions is on the rise mainly due to improved life expectancy. Successful management of these lesions is often challenging, and given that dentin can be remineralized, adverse consequences due to progression of these lesions can be prevented or minimized as such.
This study aimed to assess the effect of casein phosphopeptide amorphous calcium phosphate (CPP-ACP) and Remin-Pro remineralizing agents on dentin microhardness of non-carious dentin lesions.
This , experimental study evaluated 36 extracted sound human premolars. The teeth were decoronated at the cementoenamel junction. Enamel was removed, and dentin was exposed at the cervical third of the buccal surface. The primary microhardness of dentin was then measured. The teeth, standardized in terms of dentin microhardness, then underwent demineralization by acid etching and were subjected to microhardness test again. They were then randomized into three groups for treatment with CPP-ACP, Remin-Pro, and artificial saliva (control), and dentin microhardness was measured for the third time after treatment. Data were analyzed using ANOVA.
Within group comparisons showed a significant difference in microhardness at the three time points in all three groups (< 0.005). Between-group comparisons revealed that the microhardness of the three groups was not significantly different at baseline or after demineralization. However, the microhardness of the three groups was significantly different after the intervention (= 0.000). Pairwise comparisons revealed significantly higher microhardness in the CPP-ACP group than the other two groups (= 0.003). Remin-Pro and the control groups were not significantly different in this respect (= 0.340).
CPP-ACP can be used for remineralization of non-caries dentin lesions; however, Remin-Pro does not appear to be effective for this purpose.
非龋性牙本质病变的患病率正在上升，主要原因是预期寿命的延长。成功管理这些病变通常具有挑战性，鉴于牙本质可以再矿化，因此可以预防或最小化这些病变进展所带来的不良后果。
本研究旨在评估酪蛋白磷酸肽无定形磷酸钙（CPP-ACP）和Remin-Pro再矿化剂对非龋性牙本质病变牙本质显微硬度的影响。
本实验研究评估了36颗拔除的健康人前磨牙。在牙骨质釉质界处去除牙冠。去除釉质，在颊面颈部三分之一处暴露牙本质。然后测量牙本质的初始显微硬度。根据牙本质显微硬度进行标准化后的牙齿，通过酸蚀进行脱矿，然后再次进行显微硬度测试。然后将它们随机分为三组，分别用CPP-ACP、Remin-Pro和人工唾液（对照组）进行处理，并在处理后第三次测量牙本质显微硬度。使用方差分析对数据进行分析。
组内比较显示，所有三组在三个时间点的显微硬度均存在显著差异（<0.005）。组间比较显示，三组在基线或脱矿后的显微硬度无显著差异。然而，干预后三组的显微硬度存在显著差异（=0.000）。两两比较显示，CPP-ACP组的显微硬度显著高于其他两组（=0.003）。在这方面，Remin-Pro组和对照组无显著差异（=0.340）。
CPP-ACP可用于非龋性牙本质病变的再矿化；然而，Remin-Pro似乎对此目的无效。
