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用于细胞打印的体积增材制造：跨越行业适应性与监管前沿

Volumetric Additive Manufacturing for Cell Printing: Bridging Industry Adaptation and Regulatory Frontiers.

作者信息

Mathur Vidhi, Dsouza Vinita, Srinivasan Varadharajan, Vasanthan Kirthanashri S

机构信息

Manipal Centre for Biotherapeutics Research, Manipal Academy of Higher Education, Manipal, 576104 Karnataka, India.

Department of Civil Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576104 Karnataka, India.

出版信息

ACS Biomater Sci Eng. 2025 Jan 13;11(1):156-181. doi: 10.1021/acsbiomaterials.4c01837. Epub 2025 Jan 2.

DOI:10.1021/acsbiomaterials.4c01837
PMID:39746181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11733917/
Abstract

Volumetric additive manufacturing (VAM) is revolutionizing the field of cell printing by enabling the rapid creation of complex three-dimensional cellular structures that mimic natural tissues. This paper explores the advantages and limitations of various VAM techniques, such as holographic lithography, digital light processing, and volumetric projection, while addressing their suitability across diverse industrial applications. Despite the significant potential of VAM, challenges related to regulatory compliance and scalability persist, particularly in the context of bioprinted tissues. In India, the lack of clear regulatory guidelines and intellectual property protections poses additional hurdles for companies seeking to navigate the evolving landscape of bioprinting. This study emphasizes the importance of collaboration among industry stakeholders, regulatory agencies, and academic institutions to establish tailored frameworks that promote innovation while ensuring safety and efficacy. By bridging the gap between technological advancement and regulatory oversight, VAM can unlock new opportunities in regenerative medicine and tissue engineering, transforming patient care and therapeutic outcomes.

摘要

体积增材制造（VAM）正在彻底改变细胞打印领域，它能够快速创建模仿天然组织的复杂三维细胞结构。本文探讨了各种VAM技术的优势和局限性，如全息光刻、数字光处理和体积投影，同时讨论了它们在不同工业应用中的适用性。尽管VAM具有巨大潜力，但与监管合规性和可扩展性相关的挑战依然存在，尤其是在生物打印组织的背景下。在印度，缺乏明确的监管指南和知识产权保护给寻求在不断发展的生物打印领域发展的公司带来了额外障碍。本研究强调了行业利益相关者、监管机构和学术机构之间合作的重要性，以建立既能促进创新又能确保安全性和有效性的定制框架。通过弥合技术进步与监管监督之间的差距，VAM可以在再生医学和组织工程领域释放新机遇，改变患者护理和治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e88/11733917/31cd9af44487/ab4c01837_0010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e88/11733917/1912cceeb839/ab4c01837_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e88/11733917/72fb9ad1bf1e/ab4c01837_0008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e88/11733917/31cd9af44487/ab4c01837_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e88/11733917/eef4313b306f/ab4c01837_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e88/11733917/4f526116036b/ab4c01837_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e88/11733917/8387ddcab4c5/ab4c01837_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e88/11733917/4e2437957185/ab4c01837_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e88/11733917/ac6f83751c1b/ab4c01837_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e88/11733917/4e0946e9e042/ab4c01837_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e88/11733917/1912cceeb839/ab4c01837_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e88/11733917/72fb9ad1bf1e/ab4c01837_0008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e88/11733917/31cd9af44487/ab4c01837_0010.jpg

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Foods. 2024 Sep 28;13(19):3099. doi: 10.3390/foods13193099.
3
Cyber-biological convergence: a systematic review and future outlook.网络生物学融合：系统综述与未来展望
口腔修复学中的三维打印与CAD/CAM铣削：对未来展望的关键指标的范围综述
J Clin Med. 2025 Jul 8;14(14):4837. doi: 10.3390/jcm14144837.
4
Transformative bioprinting: 4D printing and its role in the evolution of engineering and personalized medicine.变革性生物打印：4D打印及其在工程和个性化医学发展中的作用。
Discov Nano. 2025 Jul 23;20(1):118. doi: 10.1186/s11671-025-04230-w.
Front Bioeng Biotechnol. 2024 Sep 24;12:1456354. doi: 10.3389/fbioe.2024.1456354. eCollection 2024.
4
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5
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6
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7
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8
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Biofabrication. 2023 Nov 28;16(1). doi: 10.1088/1758-5090/ad0978.
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A review of materials used in tomographic volumetric additive manufacturing.层析体积增材制造中使用材料的综述。
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10
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