Mmileng Outlwile Pako, Whata Albert, Olusanya Micheal, Mhlongo Siyabonga
Centre for Applied Data Science, University of Johannesburg, Johannesburg, South Africa.
Department of Statistics, University of Pretoria, Pretoria, South Africa.
PLoS One. 2025 Jun 4;20(6):e0313734. doi: 10.1371/journal.pone.0313734. eCollection 2025.
Malaria continues to be a severe health problem across the globe, especially within resource-limited areas which lack both skilled diagnostic personnel and diagnostic equipment. This study investigates the use of deep learning diagnosis for malaria through ConvNeXt models that incorporate transfer learning techniques with data augmentation methods for better model performance and transferability. A total number of 606276 thin blood smear images served as the final augmented dataset after the initial 27558 images underwent augmentation. The ConvNeXt Tiny model, version V1 Tiny, achieved an accuracy of 95.9%.; however, the upgraded V2 Tiny Remod version exceeded this benchmark, reaching 98.1% accuracy. The accuracy rate measured 61.4% for Swin Tiny, ResNet18 reached 62.6%, and ResNet50 obtained 81.4%. The combination of label smoothing with the AdamW optimiser produced a model which exhibited strong robustness as well as generalisability. The enhanced ConvNeXt V2 Tiny model combined with data augmentation, transfer learning techniques and explainability frameworks demonstrate a practical solution for malaria diagnosis that achieves high accuracy despite limitations of access to large datasets and microscopy expertise, often observed in resource-limited regions. The findings highlight the potential for real-time diagnostic applications in remote healthcare facilities and the viability of ConvNeXt models in enhancing malaria diagnosis globally.
疟疾仍然是全球范围内严重的健康问题,尤其是在缺乏专业诊断人员和诊断设备的资源有限地区。本研究通过ConvNeXt模型研究深度学习诊断在疟疾中的应用,该模型将迁移学习技术与数据增强方法相结合,以提高模型性能和可迁移性。在最初的27558张图像经过增强后,总共606276张薄血涂片图像作为最终的增强数据集。ConvNeXt Tiny模型(版本V1 Tiny)的准确率达到了95.9%;然而,升级后的V2 Tiny Remod版本超过了这个基准,准确率达到了98.1%。Swin Tiny的准确率为61.4%,ResNet18达到62.6%,ResNet50为81.4%。标签平滑与AdamW优化器的结合产生了一个表现出强大鲁棒性和泛化能力的模型。增强后的ConvNeXt V2 Tiny模型与数据增强、迁移学习技术和可解释性框架相结合,展示了一种疟疾诊断的实用解决方案,尽管在资源有限地区经常存在难以获取大型数据集和缺乏显微镜专业知识的限制,但该方案仍能实现高精度。研究结果突出了在远程医疗设施中进行实时诊断应用的潜力,以及ConvNeXt模型在全球范围内加强疟疾诊断的可行性。