Lilly H A, Lowbury E J
Br Med J. 1974 Nov 16;4(5941):372-4. doi: 10.1136/bmj.4.5941.372.
An evaluation of the relative effectiveness of 2% hexachlorophane and 0.75% Irgasan DP 300 bar soaps in disinfection of the hands showed that the former caused a significantly larger reduction in natural skin bacteria than the latter after one handwash and after six handwashings, three on each of two successive days. Repeated use of Irgasan DP 300 bar soap caused a significantly greater reduction in skin flora than repeated handwashings with unmedicated bar soap, but a single handwash gave no significant reduction in skin flora compared with a single use of the unmedicated soap.In a comparison of a 4% chlorhexidine detergent solution a 3% hexachlorophane detergent cream and a 2% Irgasan DP 300 detergent solution the 4% chlorhexidine detergent gave the largest mean reduction in skin bacteria after one handwash and after six handwashings and 2% Irgasan DP 300 a poor and erratic reduction after a single handwash. After six handwashings all three preparations gave large reductions in skin bacteria. The 2% Irgasan preparation showed some residual activity on the skin after handwashing though less than that with chlorhexidine and with hexachlorophane-chlorocresol detergent preparations.
一项关于2%六氯酚皂和0.75%三氯生DP 300条皂对手部消毒相对有效性的评估表明，在连续两天每天洗手三次，即洗手一次和洗手六次后，前者比后者能使天然皮肤细菌数量显著减少更多。与使用无药皂反复洗手相比，反复使用三氯生DP 300条皂能使皮肤菌群数量显著减少更多，但与单次使用无药皂相比，单次洗手对皮肤菌群数量的减少并无显著差异。在比较4%洗必泰洗涤剂溶液、3%六氯酚洗涤剂乳膏和2%三氯生DP 300洗涤剂溶液时，4%洗必泰洗涤剂在洗手一次和洗手六次后能使皮肤细菌数量平均减少最多，而2%三氯生DP 300洗涤剂在单次洗手后细菌数量减少效果较差且不稳定。洗手六次后，所有三种制剂都能使皮肤细菌数量大幅减少。2%三氯生制剂在洗手后在皮肤上显示出一定的残留活性，尽管比洗必泰和六氯酚 - 氯甲酚洗涤剂制剂的残留活性要低。
