铜绿假单胞菌毒素A在实验性大鼠烧伤创面脓毒症中的评估
Evaluation of Pseudomonas aeruginosa toxin A in experimental rat burn wound sepsis.
作者信息
Walker H L, McLeod C G, Leppla S H, Mason A D
出版信息
Infect Immun. 1979 Sep;25(3):828-30. doi: 10.1128/iai.25.3.828-830.1979.
Abstract
The search for methods to achieve control of Pseudomonas aeruginosa infection continues with the introduction of aluminum-absorbed toxoid developed from P. aeruginosa exotoxin. This toxoid induces significant titers of neutralizing and precipitating antibodies for toxin A when given with appropriate adjuvants. These experiments show that immunization with aluminum phosphate-absorbed toxoid failed to protect burned rats infected with P. aeruginosa. These and previous experiments show that active immunization with live P. aeruginosa provides good strain-specific protection in the same model. No cross-protection was demonstrated between strains of P. aeruginosa in these experiments.
摘要
随着由铜绿假单胞菌外毒素研制出的铝吸附类毒素的引入，人们仍在继续寻找控制铜绿假单胞菌感染的方法。当与适当的佐剂一起使用时，这种类毒素能诱导产生针对毒素A的显著滴度的中和抗体和沉淀抗体。这些实验表明，用磷酸铝吸附类毒素进行免疫不能保护感染铜绿假单胞菌的烧伤大鼠。这些实验以及之前的实验表明，用活的铜绿假单胞菌进行主动免疫能在同一模型中提供良好的菌株特异性保护。在这些实验中，未证明铜绿假单胞菌菌株之间存在交叉保护。
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