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多个人类β干扰素基因。

Multiple human beta interferon genes.

作者信息

Sagar A D, Sehgal P B, Slate D L, Ruddle F H

出版信息

J Exp Med. 1982 Sep 1;156(3):744-55. doi: 10.1084/jem.156.3.744.

DOI:10.1084/jem.156.3.744
PMID:6180119
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186800/
Abstract

Analysis of human beta interferon (IFN) mRNA preparations obtained from poly(I) . poly (C)-induced human diploid fibroblasts (FS-4) and from several similarly induced human-mouse somatic cell hybrids by electrophoresis through agarose-CH3HgOH tube gels led to the detection of at least five translationally active human IFN-beta mRNA species. The results obtained are consistent with the existence of IFN-beta genes on different human chromosomes. Marked cell-dependent variability in the expression of these IFN mRNA species was observed.

摘要

通过琼脂糖-甲基汞管凝胶电泳分析从聚肌苷酸-聚胞苷酸（poly(I)·poly(C)）诱导的人二倍体成纤维细胞（FS-4）以及几种类似诱导的人-鼠体细胞杂种中获得的人β干扰素（IFN）mRNA制剂，结果检测到至少五种具有翻译活性的人IFN-β mRNA种类。所得结果与不同人类染色体上存在IFN-β基因相一致。观察到这些IFN mRNA种类的表达存在明显的细胞依赖性变异性。

相似文献

1
Multiple human beta interferon genes.多个人类β干扰素基因。
J Exp Med. 1982 Sep 1;156(3):744-55. doi: 10.1084/jem.156.3.744.
2
[Cytogenetic bases of the production and action of human interferon].
Usp Sovrem Biol. 1982 May-Jun;93(3):363-81.
3
Unusually long mRNA species coding for human alpha and beta interferons.编码人α和β干扰素的异常长的mRNA种类。
Proc Natl Acad Sci U S A. 1982 Nov;79(22):6932-6. doi: 10.1073/pnas.79.22.6932.
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The somatic cell genetics of human interferon: assignment of human interferon loci to chromosomes 2 and 5.人类干扰素的体细胞遗传学：将人类干扰素基因座定位于2号和5号染色体
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2251-5. doi: 10.1073/pnas.71.6.2251.
5
Human beta interferon gene localization and expression in somatic cell hybrids.人β干扰素基因在体细胞杂种中的定位与表达
Mol Cell Biol. 1982 May;2(5):564-70. doi: 10.1128/mcb.2.5.564-570.1982.
6
Somatic cell genetic analysis of interferon production and response.
Ann N Y Acad Sci. 1980;350:174-8. doi: 10.1111/j.1749-6632.1980.tb20619.x.
7
Heterogeneity of interferon mRNA species from Sendai virus-induced human lymphoblastoid (Namalva) cells and Newcastle disease virus-induced murine fibroblastoid (L) cells.仙台病毒诱导的人淋巴母细胞样（Namalva）细胞和新城疫病毒诱导的鼠成纤维细胞样（L）细胞中干扰素mRNA种类的异质性。
Nucleic Acids Res. 1981 Jan 10;9(1):149-60. doi: 10.1093/nar/9.1.149.
8
Fibroblast interferon in man is coded by two loci on separate chromosomes.人类成纤维细胞干扰素由位于不同染色体上的两个基因座编码。
Cell. 1979 Jan;16(1):171-80. doi: 10.1016/0092-8674(79)90198-3.
9
Leukocyte and fibroblast interferon genes are located on human chromosome 9.白细胞和成纤维细胞干扰素基因位于人类第9号染色体上。
Proc Natl Acad Sci U S A. 1981 May;78(5):3123-7. doi: 10.1073/pnas.78.5.3123.
10
Interferon-beta-related DNA is dispersed in the human genome.干扰素-β相关DNA分散于人类基因组中。
Science. 1984 Mar 23;223(4642):1312-5. doi: 10.1126/science.6546621.

引用本文的文献

1
The chromosomal location of mouse interferon alpha genes.小鼠α干扰素基因的染色体定位。
EMBO J. 1984 Jul;3(7):1643-6. doi: 10.1002/j.1460-2075.1984.tb02023.x.
2
Structure and expression in Escherichia coli of a cloned rat interferon-alpha gene.克隆的大鼠α干扰素基因在大肠杆菌中的结构与表达
Nucleic Acids Res. 1984 Jan 25;12(2):1227-42. doi: 10.1093/nar/12.2.1227.
3
Isolation of novel human genomic DNA clones related to human interferon-beta 1 cDNA.与人类β-1干扰素cDNA相关的新型人类基因组DNA克隆的分离
Proc Natl Acad Sci U S A. 1983 Jun;80(12):3632-6. doi: 10.1073/pnas.80.12.3632.
4
The interferons.干扰素
Clin Exp Immunol. 1983 Oct;54(1):1-13.
5
Structure and expression of cloned murine IFN-alpha genes.克隆的小鼠α干扰素基因的结构与表达
Nucleic Acids Res. 1983 Feb 11;11(3):555-73. doi: 10.1093/nar/11.3.555.
6
Unusually long mRNA species coding for human alpha and beta interferons.编码人α和β干扰素的异常长的mRNA种类。
Proc Natl Acad Sci U S A. 1982 Nov;79(22):6932-6. doi: 10.1073/pnas.79.22.6932.
7
Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved.抗β-干扰素抗体可抑制肿瘤坏死因子处理的人成纤维细胞中HLA-B7 mRNA表达的增加：对相关β2干扰素的结构研究。
Proc Natl Acad Sci U S A. 1986 Dec;83(23):8957-61. doi: 10.1073/pnas.83.23.8957.
8
A cytokine network in human diploid fibroblasts: interactions of beta-interferons, tumor necrosis factor, platelet-derived growth factor, and interleukin-1.人二倍体成纤维细胞中的细胞因子网络：β-干扰素、肿瘤坏死因子、血小板衍生生长因子和白细胞介素-1的相互作用。
Mol Cell Biol. 1987 Jan;7(1):273-80. doi: 10.1128/mcb.7.1.273-280.1987.
9
Human chromosome 7 carries the beta 2 interferon gene.人类7号染色体携带着β2干扰素基因。
Proc Natl Acad Sci U S A. 1986 Jul;83(14):5219-22. doi: 10.1073/pnas.83.14.5219.
10
Evidence for IFN-beta heterogeneity in a substrain of Namalwa cells.
Appl Biochem Biotechnol. 1985 Apr;11(2):111-22. doi: 10.1007/BF02798543.

本文引用的文献

1
Structure of a chromosomal gene for human interferon beta.人干扰素β基因的结构。
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5305-9. doi: 10.1073/pnas.78.9.5305.
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Human fibroblast interferon: amino acid analysis and amino terminal amino acid sequence.人成纤维细胞干扰素：氨基酸分析及氨基末端氨基酸序列
Science. 1980 Feb 1;207(4430):525-6. doi: 10.1126/science.7352259.
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Synthesis in E. coli of a polypeptide with human leukocyte interferon activity.在大肠杆菌中合成具有人白细胞干扰素活性的多肽。
Nature. 1980 Mar 27;284(5754):316-20. doi: 10.1038/284316a0.
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Human beta interferon gene localization and expression in somatic cell hybrids.人β干扰素基因在体细胞杂种中的定位与表达
Mol Cell Biol. 1982 May;2(5):564-70. doi: 10.1128/mcb.2.5.564-570.1982.
5
Partial mapping of ten genes of the human interferon- alpha family.人类α-干扰素家族十个基因的部分图谱
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6
Chromosomal location of a human alpha interferon gene family.人类α干扰素基因家族的染色体定位
J Exp Med. 1982 Apr 1;155(4):1019-24. doi: 10.1084/jem.155.4.1019.
7
Procedures to estimate the size of interferon mRNA and use of UV irradiation to estimate the size of its primary transcript.
Methods Enzymol. 1981;79(Pt B):111-24. doi: 10.1016/s0076-6879(81)79021-9.
8
Further heterogeneity of human alpha interferon mRNA species.人α干扰素mRNA种类的进一步异质性。
Science. 1981 Nov 13;214(4522):803-5. doi: 10.1126/science.6170112.
9
Nucleotide sequence of the chromosomal gene for human fibroblast (beta 1) interferon and of the flanking regions.人成纤维细胞（β1）干扰素染色体基因及其侧翼区域的核苷酸序列。
Gene. 1981 Aug;14(3):137-43. doi: 10.1016/0378-1119(81)90109-8.
10
The structure of a thirty-six kilobase region of the human chromosome including the fibroblast interferon gene IFN-beta.包含成纤维细胞干扰素基因IFN-β的人类染色体三十六千碱基区域的结构。
Nucleic Acids Res. 1981 Jun 11;9(11):2495-507. doi: 10.1093/nar/9.11.2495.