多个人类β干扰素基因。
Multiple human beta interferon genes.
作者信息
Sagar A D, Sehgal P B, Slate D L, Ruddle F H
出版信息
J Exp Med. 1982 Sep 1;156(3):744-55. doi: 10.1084/jem.156.3.744.
Abstract
Analysis of human beta interferon (IFN) mRNA preparations obtained from poly(I) . poly (C)-induced human diploid fibroblasts (FS-4) and from several similarly induced human-mouse somatic cell hybrids by electrophoresis through agarose-CH3HgOH tube gels led to the detection of at least five translationally active human IFN-beta mRNA species. The results obtained are consistent with the existence of IFN-beta genes on different human chromosomes. Marked cell-dependent variability in the expression of these IFN mRNA species was observed.
摘要
通过琼脂糖-甲基汞管凝胶电泳分析从聚肌苷酸-聚胞苷酸（poly(I)·poly(C)）诱导的人二倍体成纤维细胞（FS-4）以及几种类似诱导的人-鼠体细胞杂种中获得的人β干扰素（IFN）mRNA制剂，结果检测到至少五种具有翻译活性的人IFN-β mRNA种类。所得结果与不同人类染色体上存在IFN-β基因相一致。观察到这些IFN mRNA种类的表达存在明显的细胞依赖性变异性。
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