新型β-内酰胺酶敏感显色头孢菌素试剂CENTA的体外评估
In vitro evaluation of CENTA, a new beta-lactamase-susceptible chromogenic cephalosporin reagent.
作者信息
Jones R N, Wilson H W, Novick W J, Barry A L, Thornsberry C
出版信息
J Clin Microbiol. 1982 May;15(5):954-8. doi: 10.1128/jcm.15.5.954-958.1982.
Abstract
CENTA is a newly synthesized, beta-lactamase-labile, chromogenic cephalosporin reagent which changes color from light yellow (lambda maximum ca. 340 nm) to chrome yellow (lambda maximum ca. 405 nm) concomitant with hydrolysis of the beta-lactam ring. This compound offers promise as a diagnostic reagent comparable to other chromogens (PADAC and nitrocefin) for the early detection of beta-lactamase-producing clinical isolates, while retaining some antimicrobial effect against Escherichia coli, Klebsiella spp., Proteus mirabilis, Staphylococcus aureus, and non-enterococcal Streptococcus spp. CENTA is relatively unaffected by commonly used microbiological media and human serum.
摘要
CENTA是一种新合成的、对β-内酰胺酶不稳定的生色头孢菌素试剂，它会随着β-内酰胺环的水解，从浅黄色（最大吸收波长约340nm）变为铬黄色（最大吸收波长约405nm）。作为一种诊断试剂，该化合物有望与其他显色剂（PADAC和硝噻吩）相媲美，用于早期检测产β-内酰胺酶的临床分离株，同时对大肠杆菌、克雷伯菌属、奇异变形杆菌、金黄色葡萄球菌和非肠球菌属链球菌仍保留一定抗菌作用。CENTA相对不受常用微生物培养基和人血清的影响。
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