法国奶农慢性支气管炎和农民肺的患病率及危险因素
Prevalence and risk factors for chronic bronchitis and farmer's lung in French dairy farmers.
作者信息
Dalphin J C, Debieuvre D, Pernet D, Maheu M F, Polio J C, Toson B, Dubiez A, Monnet E, Laplante J J, Depierre A
机构信息
Department of Respiratory Disease, CHR of Besançon, France.
出版信息
Br J Ind Med. 1993 Oct;50(10):941-4. doi: 10.1136/oem.50.10.941.
The prevalence of chronic bronchitis and of clinical farmer's lung was studied in 30 districts of the French Doubs province in relation to individual (age, sex, smoking) and geographical (altitude) factors. 5703 exclusively dairy farmers (response rate 83%) participated in the study by answering a medical questionnaire. Prevalences of chronic bronchitis and clinical farmer's lung were 9.3% and 1.4% respectively. A logistic regression model was used to evaluate risk factors for chronic bronchitis and clinical farmer's lung. A risk of chronic bronchitis was associated with male sex (p < 10(-4)), age (p < 10(-4)), smoker category (p < 10(-4)), and altitude (p < 10(-4)). A risk of clinical farmer's lung was associated with non-smokers (p < 0.05), and linearly with altitude (p < 10(-4)). Also there was a strong positive relation between chronic bronchitis and clinical farmer's lung (odds ratio 19.5 (95% confidence interval 12.1-31.4) after adjustment for confounding variables. The main finding of this study is the highly significant increase of prevalence of the diseases in relation to altitude.
在法国杜省的30个地区，针对个体因素（年龄、性别、吸烟情况）和地理因素（海拔），对慢性支气管炎和临床型农民肺的患病率展开了研究。5703名纯奶农（应答率83%）通过回答一份医学问卷参与了此项研究。慢性支气管炎和临床型农民肺的患病率分别为9.3%和1.4%。运用逻辑回归模型评估慢性支气管炎和临床型农民肺的风险因素。慢性支气管炎的患病风险与男性（p < 10⁻⁴）、年龄（p < 10⁻⁴）、吸烟类别（p < 10⁻⁴）以及海拔（p < 10⁻⁴）相关。临床型农民肺的患病风险与不吸烟者相关（p < 0.05），且与海拔呈线性关系（p < 10⁻⁴）。此外，在对混杂变量进行校正后，慢性支气管炎与临床型农民肺之间存在很强的正相关关系（优势比19.5（95%置信区间12.1 - 31.4））。本研究的主要发现是，这些疾病的患病率随海拔升高而显著增加。
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