School of Kinesiology, University of Minnesota, Minneapolis, MN, USA.
J Eur Acad Dermatol Venereol. 2012 Nov;26(11):1345-53. doi: 10.1111/j.1468-3083.2012.04494.x. Epub 2012 Mar 5.
Psoriasis is a common, chronic inflammatory skin disease that can cause significant discomfort and impairment to quality of life. Recent research indicates that individuals with moderate-to-severe psoriasis are likely at greater risk for chronic cardiometabolic co-morbidities such as cardiovascular disease, type 2 diabetes, obesity and metabolic syndrome. Physical activity can be an effective primary and adjunctive treatment for these maladies in other populations. Unfortunately, only a limited number of studies have examined physical activity in psoriasis, which are limited by poor design and lack of validated physical activity assessment methodologies. A variety of data suggest shared physiologic pathways between physical activity, psoriasis, and psoriasis cardiometabolic co-morbidities. Increased adiposity, inflammation, oxidative stress, adhesion molecules and lipids are physiologically linked to psoriasis, the risk of psoriasis cardiometabolic co-morbidities, and low levels of physical activity. In addition, epigenetic pathways are involved in psoriasis and could be influenced by physical activity. The physical and psychosocial impairments common in psoriasis may make it difficult to participate in regular physical activity, and future studies should aim to determine if physical activity interventions improve functioning and reduce co-morbidities in psoriasis.
银屑病是一种常见的慢性炎症性皮肤病，可导致严重的不适，并损害生活质量。最近的研究表明，中重度银屑病患者患心血管代谢合并症（如心血管疾病、2 型糖尿病、肥胖和代谢综合征）的风险更高。在其他人群中，身体活动可以作为这些疾病的有效主要和辅助治疗方法。不幸的是，只有少数研究检查了银屑病中的身体活动，这些研究受到设计不佳和缺乏经过验证的身体活动评估方法的限制。各种数据表明，身体活动、银屑病和银屑病代谢合并症之间存在共同的生理途径。肥胖、炎症、氧化应激、黏附分子和脂质与银屑病、银屑病代谢合并症的风险以及身体活动水平低有关。此外，表观遗传途径与银屑病有关，可能会受到身体活动的影响。银屑病中常见的身体和心理社会障碍可能会使其难以进行常规身体活动，未来的研究应旨在确定身体活动干预是否可以改善银屑病患者的功能并减少合并症。
