Sarvestani Amirmehdi, Karimian Ali, Mohammadi Rasool, Cheraghipour Kourosh, Zivdri Masoomeh, Nourmohammadi Morteza, Almasian Mohammad, Nafari Amirhossein
Faculty of Medicine, Lorestan University of Medical Sciences, Anooshirvan Rezaei Square, Khorramabad, Lorestan 6813833946 Iran.
Department of Epidemiology and Biostatistics, School of Public Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran.
J Parasit Dis. 2021 Mar;45(1):59-64. doi: 10.1007/s12639-020-01273-x. Epub 2020 Sep 24.
Echinococcosis is among the most underestimated parasitic diseases that have universal distribution. The primary treatment is surgery. Hence, the development of new and more effective scolicidal agents with lower side effects is crucial. This study evaluated the therapeutic effects of and extracts as a scolicidal herbal drug in vitro. Suspension of protoscoleces was obtained from the infected livers of sheep in Khorramabad, Iran. Hydro-alcoholic solution was extracted from the leaves and stems of and the fruit of . protoscoleces were treated with the essential oils at concentrations of 10, 25, 50, and 100 mg/mL for 10, 20, 30, and 60 min and their viability was evaluated by the eosin staining test. The extract of at a concentration of 100 mg/mL killed 90.51% of protoscoleces after 60 min. also killed 67.74% of protoscoleces after 60 min. This study obtained satisfactory results. and extracts are promising protoscolicides and can be used in the treatment of hydatid cysts and pre-surgically to prevent secondary infections.
棘球蚴病是分布广泛但最被低估的寄生虫病之一。主要治疗方法是手术。因此，开发新的、更有效的且副作用更低的杀头节剂至关重要。本研究评估了[植物名称1]和[植物名称2]提取物作为杀头节草药药物在体外的治疗效果。原头节悬液取自伊朗霍拉马巴德感染羊的肝脏。水醇溶液从[植物名称1]的叶和茎以及[植物名称2]的果实中提取。将原头节用浓度为10、25、50和100mg/mL的精油处理10、20、30和60分钟，并通过伊红染色试验评估其活力。[植物名称1]提取物在浓度为100mg/mL时，60分钟后杀死了90.51%的原头节。[植物名称2]在60分钟后也杀死了67.74%的原头节。本研究取得了满意的结果。[植物名称1]和[植物名称2]提取物是有前景的杀原头节剂，可用于治疗包虫囊肿，并在术前使用以预防继发感染。
