病毒进入机制研究的新突破
A new player in the puzzle of filovirus entry.
机构信息
Department of Cell Biology, University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, Virginia 22908-20732, USA.
出版信息
Nat Rev Microbiol. 2012 Apr 11;10(5):317-22. doi: 10.1038/nrmicro2764.
Abstract
Viruses of the genera Ebolavirus and Marburgvirus are filoviruses that cause haemorrhagic fever in primates, with extremely high fatality rates. Studies have focused on elucidating how these viruses enter host cells, with the aim of developing therapeutics. The ebolavirus glycoprotein has been found to play key parts in all steps of entry. Furthermore, recent studies have identified Niemann-Pick C1 (NPC1), a protein that resides deep in the endocytic pathway, as an important host factor in this process.
摘要
埃博拉病毒属和马尔堡病毒属的病毒为丝状病毒，可引起灵长类动物的出血热，死亡率极高。研究重点是阐明这些病毒如何进入宿主细胞，以期开发出治疗方法。已发现埃博拉病毒糖蛋白在进入的所有步骤中都起着关键作用。此外，最近的研究还确定了尼曼-匹克 C1（NPC1），一种位于内吞途径深处的蛋白质，是该过程中的一个重要宿主因子。
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