Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA., Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02139, USA.
Adv Mater. 2013 Nov 26;25(44):6385-91. doi: 10.1002/adma.201301082. Epub 2013 Sep 1.
Incorporating graphene oxide inside GelMA hydrogels enhances their mechanical properties and reduces UV-induced cell damage while preserving their favorable characteristics for 3D cell encapsulation. NIH-3T3 fibroblasts encapsulated in GO-GelMA microgels demonstrate excellent cellular viability, proliferation, spreading, and alignment. GO reinforcement combined with a multi-stacking approach offers a facile engineering strategy for the construction of complex artificial tissues.
将氧化石墨烯掺入 GelMA 水凝胶中可增强其机械性能，降低 UV 诱导的细胞损伤，同时保持其对 3D 细胞包封的有利特性。包封在 GO-GelMA 微凝胶中的 NIH-3T3 成纤维细胞表现出优异的细胞活力、增殖、扩展和排列。GO 增强与多堆叠方法相结合，为构建复杂的人工组织提供了一种简单的工程策略。
