• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

采用 和 提取物的银-氧化锰纳米粒子的绿色合成及其体外细胞毒性。

Green Synthesis of Ag-MnO Nanoparticles using and Extracts and Their In Vitro Cytotoxicity.

机构信息

Babeș-Bolyai University, Faculty of Biology and Geology, 44 Republicii, 400015 Cluj-Napoca, Romania.

National Institute for Research and Development of Isotopic and Molecular Technologies, 400293 Cluj-Napoca, Romania.

出版信息

Molecules. 2020 Feb 13;25(4):819. doi: 10.3390/molecules25040819.

DOI:10.3390/molecules25040819
PMID:32070017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7070435/
Abstract

Medicinal plants are often used as reducing agents to prepare metal nanoparticles through green-synthesis due to natural compounds and their potential as chemotherapeutic drugs. Thus, three types of eco-friendly Ag-MnO nanoparticles (Ag-MnONPs) were synthesized using (CmNPs), (VmNPs), and a 1:1 mixture of the two extracts (MNPs). These NPs were characterized using S/TEM, EDX, XRD, and FTIR methods, and their biological activity was assessed in vitro on normal keratinocytes (HaCaT) and skin melanoma cells (A375). All synthesized NPs had manganese oxide in the middle, and silver oxide and plant extract on the exterior. The NPs had different forms (polygonal, oval, and spherical), uniformly distributed, with crystalline structures and different sizes (9.3 nm for MNPs; 10 nm for VmNPs, and 32.4 nm for CmNPs). The best results were obtained with VmNPs, which reduced the viability of A375 cells up 38.8% and had a moderate cytotoxic effect on HaCaT (46.4%) at concentrations above 500 µg/mL. At the same concentrations, CmNPs had a rather proliferative effect, whereas MNPs negatively affected both cell lines. For the first time, this paper proved the synergistic action of the combined and extracts to form small and uniformly distributed Ag-MnONPs with high potential for selective treatments.

摘要

药用植物常被用作还原剂，通过绿色合成来制备金属纳米粒子，因为天然化合物及其作为化疗药物的潜力。因此，使用三种环保型 Ag-MnO 纳米粒子 (Ag-MnONPs)：（CmNPs）、（VmNPs）和两种提取物的 1:1 混合物（MNPs）。使用 S/TEM、EDX、XRD 和 FTIR 方法对这些 NPs 进行了表征，并在体外评估了它们对正常角质形成细胞 (HaCaT) 和皮肤黑素瘤细胞 (A375) 的生物活性。所有合成的 NPs 中间都有氧化锰，外部有氧化银和植物提取物。这些 NPs 具有不同的形态（多边形、椭圆形和球形），分布均匀，具有结晶结构和不同的尺寸（MNPs 为 9.3nm；VmNPs 为 10nm；CmNPs 为 32.4nm）。VmNPs 效果最佳，将 A375 细胞的存活率降低了 38.8%，在 500μg/mL 以上浓度时对 HaCaT 具有中度细胞毒性作用（46.4%）。在相同浓度下，CmNPs 具有促进增殖的作用，而 MNPs 则对两种细胞系均有负面影响。本文首次证明了 和 提取物的协同作用，形成了具有高选择性治疗潜力的小而均匀分布的 Ag-MnONPs。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/2ee2984dc9cc/molecules-25-00819-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/a4c07eb3df0e/molecules-25-00819-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/ea51ab9376ad/molecules-25-00819-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/2d1a3de1ffd4/molecules-25-00819-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/2fc41695434d/molecules-25-00819-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/962241b030c1/molecules-25-00819-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/e43a09018748/molecules-25-00819-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/ba4dbe62e1d5/molecules-25-00819-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/b6494cd7dade/molecules-25-00819-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/891c94f34055/molecules-25-00819-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/ad22f2b955c0/molecules-25-00819-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/2ee2984dc9cc/molecules-25-00819-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/a4c07eb3df0e/molecules-25-00819-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/ea51ab9376ad/molecules-25-00819-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/2d1a3de1ffd4/molecules-25-00819-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/2fc41695434d/molecules-25-00819-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/962241b030c1/molecules-25-00819-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/e43a09018748/molecules-25-00819-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/ba4dbe62e1d5/molecules-25-00819-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/b6494cd7dade/molecules-25-00819-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/891c94f34055/molecules-25-00819-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/ad22f2b955c0/molecules-25-00819-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d151/7070435/2ee2984dc9cc/molecules-25-00819-g011.jpg

相似文献

1
Green Synthesis of Ag-MnO Nanoparticles using and Extracts and Their In Vitro Cytotoxicity.采用 和 提取物的银-氧化锰纳米粒子的绿色合成及其体外细胞毒性。
Molecules. 2020 Feb 13;25(4):819. doi: 10.3390/molecules25040819.
2
Plant extract-mediated biogenic synthesis of silver, manganese dioxide, silver-doped manganese dioxide nanoparticles and their antibacterial activity against food- and water-borne pathogens.植物提取物介导的银、二氧化锰、银掺杂二氧化锰纳米颗粒的生物合成及其对食源性病原体和水源性病原体的抗菌活性。
Bioprocess Biosyst Eng. 2016 May;39(5):759-72. doi: 10.1007/s00449-016-1556-2. Epub 2016 Feb 8.
3
Green synthesis of water-soluble nontoxic inorganic polymer nanocomposites containing silver nanoparticles using white tea extract and assessment of their in vitro antioxidant and cytotoxicity activities.采用白茶提取物绿色合成含银纳米粒子的水溶性无毒无机聚合物纳米复合材料，并评估其体外抗氧化和细胞毒性活性。
Mater Sci Eng C Mater Biol Appl. 2018 Jun 1;87:139-148. doi: 10.1016/j.msec.2018.02.026. Epub 2018 Mar 1.
4
Determination of Selected Isoquinoline Alkaloids from , and Extracts by Liquid Chromatography and Their In Vitro and In Vivo Cytotoxic Activity against Human Cancer Cells.采用液相色谱法测定 、 和 提取物中的几种异喹啉生物碱及其对人癌细胞的体外和体内细胞毒性活性。
Int J Mol Sci. 2023 Mar 28;24(7):6360. doi: 10.3390/ijms24076360.
5
Facile green synthesis of silver nanoparticles using seed aqueous extract of Pistacia atlantica and its antibacterial activity.利用大西洋黄连木种子水提取物简便绿色合成银纳米颗粒及其抗菌活性。
Spectrochim Acta A Mol Biomol Spectrosc. 2015 Jan 5;134:326-32. doi: 10.1016/j.saa.2014.05.078. Epub 2014 Jun 19.
6
The impact of anticancer activity upon Beta vulgaris extract mediated biosynthesized silver nanoparticles (ag-NPs) against human breast (MCF-7), lung (A549) and pharynx (Hep-2) cancer cell lines.甜菜根提取物介导生物合成的银纳米粒子 (ag-NPs) 对抗人类乳腺癌 (MCF-7)、肺癌 (A549) 和咽癌 (Hep-2) 细胞系的抗癌活性的影响。
J Photochem Photobiol B. 2017 Aug;173:99-107. doi: 10.1016/j.jphotobiol.2017.05.031. Epub 2017 May 24.
7
Rapid biosynthesis and characterization of silver nanoparticles from the leaf extract of Tropaeolum majus L. and its enhanced in-vitro antibacterial, antifungal, antioxidant and anticancer properties.从金莲花叶提取物中快速生物合成和表征银纳米粒子及其增强的体外抗菌、抗真菌、抗氧化和抗癌特性。
J Photochem Photobiol B. 2019 Feb;191:65-74. doi: 10.1016/j.jphotobiol.2018.12.010. Epub 2018 Dec 14.
8
Green synthesis of MnO nanoparticles from Psidium guajava leaf extract: Morphological characterization, photocatalytic and DNA/BSA interaction studies.由番石榴叶提取物的绿色合成 MnO 纳米粒子：形态特征、光催化和 DNA/BSA 相互作用研究。
Int J Biol Macromol. 2024 Feb;258(Pt 2):128869. doi: 10.1016/j.ijbiomac.2023.128869. Epub 2023 Dec 17.
9
In vitro and in vivo investigations on the antitumour activity of Chelidonium majus.白屈菜抗肿瘤活性的体外和体内研究。
Phytomedicine. 2015 Dec 15;22(14):1279-87. doi: 10.1016/j.phymed.2015.10.013. Epub 2015 Nov 10.
10
Rapeseed flower pollen bio-green synthesized silver nanoparticles: a promising antioxidant, anticancer and antiangiogenic compound.油菜花粉生物绿色合成银纳米粒子：一种有前途的抗氧化、抗癌和抗血管生成化合物。
J Biol Inorg Chem. 2019 May;24(3):395-404. doi: 10.1007/s00775-019-01655-4. Epub 2019 Mar 29.

引用本文的文献

1
Herbal bioactive-loaded biopolymeric formulations for wound healing applications.用于伤口愈合的负载草药生物活性成分的生物聚合物制剂。
RSC Adv. 2025 Apr 17;15(16):12402-12442. doi: 10.1039/d4ra08604j. eCollection 2025 Apr 16.
2
Enhancing Wound Healing: A Comprehensive Review of Sericin and L. as Potential Dressings.促进伤口愈合：对丝胶蛋白和潜在敷料乳酸菌的综合综述。
Materials (Basel). 2024 Aug 24;17(17):4199. doi: 10.3390/ma17174199.
3
Pharmacological Potential of Three Berberine-Containing Plant Extracts Obtained from L., (Pursh) Nutt., and Rupr.

本文引用的文献

1
Are Environmental Interventions Targeting Skin Cancer Prevention among Children and Adolescents Effective? A Systematic Review.环境干预措施是否能有效预防儿童和青少年的皮肤癌？系统评价。
Int J Environ Res Public Health. 2020 Jan 14;17(2):529. doi: 10.3390/ijerph17020529.
2
Comparison of Anticancer Activity and HPLC-DAD Determination of Selected Isoquinoline Alkaloids from , sp. and Extracts.来自[具体植物名称1]和[具体植物名称2]的特定异喹啉生物碱的抗癌活性比较及高效液相色谱-二极管阵列检测法测定和提取物
Molecules. 2019 Sep 20;24(19):3417. doi: 10.3390/molecules24193417.
3
Synthesis of silver nanoparticles using plant derived 4-N-methyl benzoic acid and evaluation of antimicrobial, antioxidant and antitumor activity.
从L.、(Pursh) Nutt.和Rupr.中获得的三种含小檗碱植物提取物的药理潜力
Biomedicines. 2024 Jun 17;12(6):1339. doi: 10.3390/biomedicines12061339.
4
Decavanadate-Bearing Guanidine Derivatives Developed as Antimicrobial and Antitumor Species.含十钒酸盐的胍衍生物的开发作为抗菌和抗肿瘤物质。
Int J Mol Sci. 2023 Dec 5;24(24):17137. doi: 10.3390/ijms242417137.
5
Comparison of In Vitro Antimelanoma and Antimicrobial Activity of 2,3-Indolo-betulinic Acid and Its Glycine Conjugates.2,3-吲哚桦木酸及其甘氨酸缀合物的体外抗黑色素瘤和抗菌活性比较
Plants (Basel). 2023 Mar 9;12(6):1253. doi: 10.3390/plants12061253.
6
Combined Synthesis of Cerium Oxide Particles for Effective Anti-Bacterial and Anti-Cancer Nanotherapeutics.用于有效抗菌和抗癌纳米治疗的氧化铈颗粒的联合合成。
Int J Nanomedicine. 2022 Nov 30;17:5733-5746. doi: 10.2147/IJN.S379689. eCollection 2022.
7
Fabrication of Grown Hydroxyapatite Nanoparticles Modified Porous Polyetheretherketone Matrix Composites to Promote Osteointegration and Enhance Bone Repair.制备生长型羟基磷灰石纳米颗粒改性的多孔聚醚醚酮基复合材料以促进骨整合并增强骨修复
Front Bioeng Biotechnol. 2022 Feb 28;10:831288. doi: 10.3389/fbioe.2022.831288. eCollection 2022.
8
Biogenic Synthesis of MnO Nanoparticles With Leaf Extract of for Enhanced Antioxidant, Antimicrobial, Cytotoxic, and Biocompatible Applications.利用[植物名称]叶提取物生物合成二氧化锰纳米颗粒用于增强抗氧化、抗菌、细胞毒性及生物相容性应用
Front Microbiol. 2021 Nov 1;12:761084. doi: 10.3389/fmicb.2021.761084. eCollection 2021.
9
Role of Oxidative Stress in LaO Nanoparticle-Induced Cytotoxicity and Apoptosis in CHANG and HuH-7 Cells.氧化应激在 LaO 纳米颗粒诱导的 CHANG 和 HuH-7 细胞毒性和凋亡中的作用。
Int J Nanomedicine. 2021 May 20;16:3487-3496. doi: 10.2147/IJN.S302478. eCollection 2021.
利用植物源4-甲基苯甲酸合成银纳米颗粒及其抗菌、抗氧化和抗肿瘤活性评估。
Saudi J Biol Sci. 2019 Jul;26(5):970-978. doi: 10.1016/j.sjbs.2019.04.001. Epub 2019 Apr 3.
4
Role of Nanoparticle Mechanical Properties in Cancer Drug Delivery.纳米颗粒机械性能在癌症药物输送中的作用。
ACS Nano. 2019 Jul 23;13(7):7410-7424. doi: 10.1021/acsnano.9b03924. Epub 2019 Jul 11.
5
Investigating the effect of near infrared photo thermal therapy folic acid conjugated gold nano shell on melanoma cancer cell line A375.研究近红外光热疗法叶酸偶联金纳米壳对黑色素瘤癌细胞系 A375 的影响。
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):2161-2170. doi: 10.1080/21691401.2019.1593188.
6
Rapeseed flower pollen bio-green synthesized silver nanoparticles: a promising antioxidant, anticancer and antiangiogenic compound.油菜花粉生物绿色合成银纳米粒子：一种有前途的抗氧化、抗癌和抗血管生成化合物。
J Biol Inorg Chem. 2019 May;24(3):395-404. doi: 10.1007/s00775-019-01655-4. Epub 2019 Mar 29.
7
Toxic effects of magnetic nanoparticles on normal cells and organs.磁性纳米粒子对正常细胞和器官的毒性作用。
Life Sci. 2019 Mar 1;220:156-161. doi: 10.1016/j.lfs.2019.01.056. Epub 2019 Feb 1.
8
Cancer statistics, 2019.癌症统计数据，2019 年。
CA Cancer J Clin. 2019 Jan;69(1):7-34. doi: 10.3322/caac.21551. Epub 2019 Jan 8.
9
Anticancer Activity of Natural Compounds from Plant and Marine Environment.植物和海洋环境天然产物的抗癌活性。
Int J Mol Sci. 2018 Nov 9;19(11):3533. doi: 10.3390/ijms19113533.
10
A review on silver nanoparticles-induced ecotoxicity and the underlying toxicity mechanisms.关于银纳米粒子诱导的生态毒性及其潜在毒性机制的综述。
Regul Toxicol Pharmacol. 2018 Oct;98:231-239. doi: 10.1016/j.yrtph.2018.08.003. Epub 2018 Aug 7.