Laboratory of Systems Biomedical Science, Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Institute of Food Safety and Health Risk Assessment, National Yang-Ming University, Taipei, Taiwan, ROC.
J Chin Med Assoc. 2020 Aug;83(8):701-703. doi: 10.1097/JCMA.0000000000000337.
The recent outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been causing respiratory diseases globally, damaging wide ranges of social-economic activities. This virus is transmitted through personal contact and possibly also through ambient air. Effective biosensor platforms for the detection of this virus and the related host response are in urgent demand. These platforms can facilitate routine diagnostic assays in certified clinical laboratories. They can also be integrated into point-of-care products. Furthermore, environmental biosensors can be designed to detect SARS-CoV-2 in the ambient air or in the intensive care ventilators. Here, we evaluate technical components of biosensors, including the biological targets of recognition, the recognition methods, and the signal amplification and transduction systems. Effective SARS-CoV-2 detectors can be designed by an adequate combination of these technologies.
最近严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 大流行的爆发在全球范围内引发了呼吸道疾病，破坏了广泛的社会经济活动。这种病毒通过人际接触传播，也可能通过环境空气传播。人们迫切需要用于检测这种病毒及其相关宿主反应的有效生物传感器平台。这些平台可以促进在经过认证的临床实验室进行常规诊断检测。它们也可以集成到即时检测产品中。此外，环境生物传感器可以设计用于检测环境空气中或重症监护通风机中的 SARS-CoV-2。在这里，我们评估了生物传感器的技术组件，包括识别的生物靶标、识别方法以及信号放大和转导系统。通过适当组合这些技术，可以设计出有效的 SARS-CoV-2 检测器。
