Egger Andjela, Tomic-Canic Marjana, Tosti Antonella
Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, U.S.A.
CellR4 Repair Replace Regen Reprogram. 2020;8. Epub 2020 Sep 2.
Hair loss is a quite common condition observed in both men and women. Pattern hair loss also known as androgenetic alopecia is the most common form of hair loss that is thought to affect up to 80% of Caucasian men and up to 40% of Caucasian women by age of 70, and it can have quite devastating consequences on one's well-being, including lower self-esteem, depression and lower quality of life. To date there have only been 2 FDA approved medications, minoxidil and finasteride, but their effects are often unsatisfactory and temporary, in addition to having various adverse effects. Stem cell-based therapies have recently received lots of attention as potential novel treatments that focus on reactivating hair follicle stem cells and in this way enhance hair follicle growth, regeneration and development. Stem cell-based therapy approaches include stem cell transplant, stem cell-derived conditioned medium and stem cell-derived exosomes.
A combination of following key words was utilized for a PubMed search: cell-based therapy, hair loss, alopecia, hair regrowth; abstracts were screened and included based on the content relevant to hair loss and stem-cell based therapy.
Preclinical research utilizing these approaches has blossomed in the past decade along with a more limited number of clinical studies, overall demonstrating very promising findings.
However, stem cell-based therapies for hair loss are still at their infancy and more robust clinical studies are needed to better evaluate their mechanisms of action, efficacy, safety, benefits and limitations. In this review, we provide the resources to the latest preclinical studies and a more detailed description of the latest clinical studies concerning stem cell-based therapies in hair loss.
脱发是男性和女性中都很常见的一种情况。型脱发也称为雄激素性脱发，是最常见的脱发形式，据认为，到70岁时，高达80%的白人男性和高达40%的白人女性会受到影响，它会对人的幸福感产生相当严重的后果，包括自尊心下降、抑郁和生活质量降低。迄今为止，美国食品药品监督管理局（FDA）仅批准了两种药物，即米诺地尔和非那雄胺，但它们的效果往往不尽人意且是暂时的，此外还存在各种不良反应。基于干细胞的疗法最近作为潜在的新型治疗方法受到了广泛关注，这些疗法专注于重新激活毛囊干细胞，从而促进毛囊生长、再生和发育。基于干细胞的治疗方法包括干细胞移植、干细胞衍生的条件培养基和干细胞衍生的外泌体。
使用以下关键词组合在PubMed上进行搜索：基于细胞的疗法、脱发、秃发、毛发生长；根据与脱发和基于干细胞的疗法相关的内容筛选并纳入摘要。
在过去十年中，利用这些方法的临床前研究蓬勃发展，同时临床研究数量相对有限，总体显示出非常有前景的结果。
然而，基于干细胞的脱发治疗仍处于起步阶段，需要更有力的临床研究来更好地评估其作用机制、疗效、安全性、益处和局限性。在本综述中，我们提供了有关最新临床前研究的资源，以及对有关基于干细胞的脱发治疗的最新临床研究的更详细描述。
