Claesen Jan, Spagnolo Jennifer B, Ramos Stephany Flores, Kurita Kenji L, Byrd Allyson L, Aksenov Alexander A, Melnik Alexey V, Wong Weng R, Wang Shuo, Hernandez Ryan D, Donia Mohamed S, Dorrestein Pieter C, Kong Heidi H, Segre Julia A, Linington Roger G, Fischbach Michael A, Lemon Katherine P
Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Microbiology, Forsyth Institute, Cambridge, MA 02142, USA.
Sci Transl Med. 2020 Nov 18;12(570). doi: 10.1126/scitranslmed.aay5445.
The composition of the skin microbiota varies widely among individuals when sampled at the same body site. A key question is which molecular factors determine strain-level variability within sub-ecosystems of the skin microbiota. Here, we used a genomics-guided approach to identify an antibacterial biosynthetic gene cluster in (formerly ), a human skin commensal bacterium that is widely distributed across individuals and skin sites. Experimental characterization of this biosynthetic gene cluster resulted in identification of a new thiopeptide antibiotic, cutimycin. Analysis of individual human skin hair follicles revealed that cutimycin contributed to the ecology of the skin hair follicle microbiota and helped to reduce colonization of skin hair follicles by species.
当在相同身体部位进行采样时，个体之间皮肤微生物群的组成差异很大。一个关键问题是，哪些分子因素决定了皮肤微生物群亚生态系统内菌株水平的变异性。在这里，我们采用了一种基因组学指导的方法，在（以前称为）中鉴定出一个抗菌生物合成基因簇，这是一种人类皮肤共生细菌，广泛分布于个体和皮肤部位。对该生物合成基因簇的实验表征导致鉴定出一种新的硫肽抗生素——皮肤霉素。对个体人类皮肤毛囊的分析表明，皮肤霉素有助于皮肤毛囊微生物群的生态，并有助于减少物种对皮肤毛囊的定植。
