无症状西班牙裔人群中幽门螺杆菌感染和组织学胃炎的高患病率。
High prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic Hispanics.
作者信息
Dehesa M, Dooley C P, Cohen H, Fitzgibbons P L, Perez-Perez G I, Blaser M J
机构信息
Department of Medicine, University of Southern California School of Medicine, Los Angeles 90033.
出版信息
J Clin Microbiol. 1991 Jun;29(6):1128-31. doi: 10.1128/jcm.29.6.1128-1131.1991.
In this study, we estimated the prevalence of Helicobacter pylori infection and histologic gastritis in 58 asymptomatic Hispanic adult volunteers (mean age, 41 years; 59% male) by endoscopic biopsy of the upper gastrointestinal tract. Forty-six subjects (79%) were found to harbor H. pylori in gastric biopsies, and all had histologic gastritis. Four other subjects were found to have gastritis in the absence of H. pylori. Similar prevalences of H. pylori and gastritis were noted in all age groups and also in American-born and immigrant Hispanics. Biopsy data and serologic studies of H. pylori antibodies correlated well. We conclude that H. pylori infection is an almost universal finding in the gastric mucosa of asymptomatic adult Hispanics, regardless of age. The clinical significance of these findings is unknown, but we speculate that H. pylori and its associated gastritis could have a role in the high incidence of gastric carcinoma in Hispanic populations.
在本研究中，我们通过上消化道内镜活检，对58名无症状的西班牙裔成年志愿者（平均年龄41岁；59%为男性）的幽门螺杆菌感染率和组织学胃炎情况进行了评估。在胃活检中发现46名受试者（79%）感染了幽门螺杆菌，且均患有组织学胃炎。另外4名受试者在未感染幽门螺杆菌的情况下患有胃炎。在所有年龄组以及在美国出生和移民的西班牙裔中，幽门螺杆菌和胃炎的患病率相似。幽门螺杆菌活检数据与血清学抗体研究结果相关性良好。我们得出结论，无论年龄大小，幽门螺杆菌感染在无症状成年西班牙裔的胃黏膜中几乎普遍存在。这些发现的临床意义尚不清楚，但我们推测幽门螺杆菌及其相关胃炎可能在西班牙裔人群胃癌的高发病率中起作用。
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