Zhang Li-Min, Liu Zhan, Wang Jia-Qi, Li Rui-Qiang, Ren Jing-Yi, Gao Xian, Lv Shuai-Shuai, Liang Lu-Yao, Zhang Fan, Yin Bo-Wen, Sun Yan, Tian Hao, Zhu Hui-Chen, Zhou Yu-Tian, Ma Yu-Xia
Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Hebei Key Laboratory of Environment and Human Health, Shijiazhuang 050017, China.
iScience. 2022 Aug 5;25(9):104870. doi: 10.1016/j.isci.2022.104870. eCollection 2022 Sep 16.
Time-restricted eating (TRE) is known to improve metabolic health, whereas very few studies have compared the effects of early and late TRE (eTRE and lTRE) on metabolic health. Overweight and obese young adults were randomized to 6-h eTRE (eating from 7 a.m. to 1 p.m.) (n = 21), 6-h lTRE (eating from 12 p.m. to 6 p.m.) (n = 20), or a control group ( intake in a day) (n = 19). After 8 weeks, 6-h eTRE and lTRE produced comparable body weight loss compared with controls. Compared with control, 6-h eTRE reduced systolic blood pressure, mean glucose, fasting insulin, insulin resistance, leptin, and thyroid axis activity, whereas lTRE only reduced leptin. These findings shed light on the promise of 6-h eTRE and lTRE for weight loss. Larger studies are needed to assess the promise of eTRE to yield better thyroid axis modulation and overall cardiometabolic health improvement.
限时进食（TRE）已知可改善代谢健康，然而很少有研究比较早期和晚期限时进食（eTRE和lTRE）对代谢健康的影响。超重和肥胖的年轻成年人被随机分为6小时的eTRE组（上午7点至下午1点进食）（n = 21）、6小时的lTRE组（中午12点至下午6点进食）（n = 20）或对照组（一天内随意进食）（n = 19）。8周后，与对照组相比，6小时的eTRE和lTRE导致的体重减轻相当。与对照组相比，6小时的eTRE降低了收缩压、平均血糖、空腹胰岛素、胰岛素抵抗、瘦素和甲状腺轴活性，而lTRE仅降低了瘦素。这些发现揭示了6小时的eTRE和lTRE在减肥方面的前景。需要进行更大规模的研究来评估eTRE在产生更好的甲状腺轴调节和整体心血管代谢健康改善方面的前景。
