睡眠剥夺对夜间哮喘患者夜间支气管收缩的影响。
Effect of sleep deprivation on overnight bronchoconstriction in nocturnal asthma.
作者信息
Catterall J R, Rhind G B, Stewart I C, Whyte K F, Shapiro C M, Douglas N J
出版信息
Thorax. 1986 Sep;41(9):676-80. doi: 10.1136/thx.41.9.676.
Nocturnal cough and wheeze are common in asthma. The cause of nocturnal asthma is unknown and there is conflicting evidence on whether sleep is a factor. Twelve adult asthmatic subjects with nocturnal wheeze were studied on two occasions: on one night subjects were allowed to sleep and on the other they were kept awake all night, wakefulness being confirmed by electroencephalogram. Every patient developed bronchoconstriction overnight both on the asleep night, when peak expiratory flow (PEF) fell from a mean (SE) of 418 (40) 1 min-1 at 10 pm to 270 (46) 1 min-1 in the morning, and on the awake night (PEF 10 pm 465 (43), morning 371 (43) 1 min-1). The morning values of PEF were, however, higher (p less than 0.1) after the awake night and both the absolute and the percentage overnight falls in PEF were greater when the patients slept (asleep night 38% (6%), awake night 20% (4%); p less than 0.01). This study suggests that sleep is an important factor in determining overnight bronchoconstriction in patients with nocturnal asthma.
夜间咳嗽和喘息在哮喘患者中很常见。夜间哮喘的病因尚不清楚，关于睡眠是否是一个因素也存在相互矛盾的证据。对12名有夜间喘息的成年哮喘患者进行了两次研究：一次让患者在夜间睡眠，另一次让他们整夜保持清醒，通过脑电图确认清醒状态。每位患者在夜间睡眠时和整夜清醒时均出现了夜间支气管收缩，在睡眠的夜间，呼气峰值流速（PEF）从晚上10点时平均（标准误）418（40）升/分钟降至早上的270（46）升/分钟，在清醒的夜间（晚上10点时PEF为465（43），早上为371（43）升/分钟）。然而，在清醒的夜间后，早上的PEF值更高（p<0.1），并且当患者睡眠时，PEF的夜间绝对下降值和下降百分比均更大（睡眠的夜间为38%（6%），清醒的夜间为20%（4%）；p<0.01）。这项研究表明，睡眠是决定夜间哮喘患者夜间支气管收缩的一个重要因素。
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