Department of Health Information Management, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Surrey Business School, University of Surrey, Guildford Surrey, GU2 7XH, UK.
Neuroinformatics. 2024 Jan;22(1):89-105. doi: 10.1007/s12021-023-09646-2. Epub 2023 Dec 2.
Recently, the early diagnosis of Alzheimer's disease has gained major attention due to the growing prevalence of the disease and the resulting costs imposed on individuals and society. The main objective of this study was to propose an ensemble method based on deep learning for the early diagnosis of AD using MRI images. The methodology of this study consisted of collecting the dataset, preprocessing, creating the individual and ensemble models, evaluating the models based on ADNI data, and validating the trained model based on the local dataset. The proposed method was an ensemble approach selected through a comparative analysis of various ensemble scenarios. Finally, the six best individual CNN-based classifiers were selected to combine and constitute the ensemble model. The evaluation showed an accuracy rate of 98.57, 96.37, 94.22, 99.83, 93.88, and 93.92 for NC/AD, NC/EMCI, EMCI/LMCI, LMCI/AD, four-way and three-way classification groups, respectively. The validation results on the local dataset revealed an accuracy of 88.46 for three-way classification. Our performance results were higher than most reviewed studies and comparable with others. Although comparative analysis showed superior results of ensemble methods against individual architectures, there were no significant differences among various ensemble approaches. The validation results revealed the low performance of individual models in practice. In contrast, the ensemble method showed promising results. However, further studies on various and larger datasets are required to validate the generalizability of the model.
近年来,由于阿尔茨海默病的发病率不断上升以及由此给个人和社会带来的成本增加,阿尔茨海默病的早期诊断受到了极大关注。本研究的主要目的是提出一种基于深度学习的集成方法,使用 MRI 图像对 AD 进行早期诊断。该研究的方法学包括收集数据集、预处理、创建个体和集成模型、基于 ADNI 数据评估模型以及基于本地数据集验证训练模型。所提出的方法是通过对各种集成方案进行比较分析选择的集成方法。最后,选择了六个基于 CNN 的最佳个体分类器进行组合,构成集成模型。评估结果显示,NC/AD、NC/EMCI、EMCI/LMCI、LMCI/AD、四分类和三分类组的准确率分别为 98.57%、96.37%、94.22%、99.83%、93.88%和 93.92%。在本地数据集上的验证结果显示三分类的准确率为 88.46%。我们的性能结果高于大多数综述研究,并与其他研究相当。虽然比较分析显示集成方法相对于个体架构具有优越的结果,但各种集成方法之间没有显著差异。验证结果表明个体模型在实际应用中的性能较低。相比之下,集成方法显示出有前景的结果。然而,需要对各种更大的数据集进行进一步研究,以验证模型的泛化能力。
Neuroscience. 2021-4-15
Comput Biol Med. 2022-7
Annu Int Conf IEEE Eng Med Biol Soc. 2021-11
Int J Neural Syst. 2020-6
BMC Med Inform Decis Mak. 2025-7-1
Diagnostics (Basel). 2024-11-23
Front Psychiatry. 2024-6-24
Comput Biol Med. 2022-7
Sensors (Basel). 2021-11-17
J Neurosci Methods. 2022-1-1
Sensors (Basel). 2021-6-18