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一种人白细胞干扰素的氨基酸序列。

Amino acid sequence of a human leukocyte interferon.

作者信息

Levy W P, Rubinstein M, Shively J, Del Valle U, Lai C Y, Moschera J, Brink L, Gerber L, Stein S, Pestka S

出版信息

Proc Natl Acad Sci U S A. 1981 Oct;78(10):6186-90. doi: 10.1073/pnas.78.10.6186.

DOI:10.1073/pnas.78.10.6186
PMID:6171813
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC349003/
Abstract

The primary structures of three major species of human leukocyte interferon differ from the structure predicted from the DNA sequence of recombinants containing leukocyte interferon-coding regions. Compared to the recombinant interferon produced in bacteria, three of the purified natural proteins isolated from leukocytes lack the 10 COOH-terminal amino acids suggested by the DNA sequence.

摘要

人类白细胞干扰素三种主要类型的一级结构与含有白细胞干扰素编码区的重组体DNA序列所预测的结构不同。与在细菌中产生的重组干扰素相比，从白细胞中分离出的三种纯化天然蛋白缺少DNA序列所显示的10个羧基末端氨基酸。

相似文献

1
Amino acid sequence of a human leukocyte interferon.一种人白细胞干扰素的氨基酸序列。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6186-90. doi: 10.1073/pnas.78.10.6186.
2
Amino-terminal amino acid sequence of human leukocyte interferon.人白细胞干扰素的氨基末端氨基酸序列
Proc Natl Acad Sci U S A. 1980 Sep;77(9):5102-4. doi: 10.1073/pnas.77.9.5102.
3
Purification and characterization of recombinant human leukocyte interferon (IFLrA) with monoclonal antibodies.利用单克隆抗体对重组人白细胞干扰素（IFLrA）进行纯化与特性鉴定
J Biol Chem. 1981 Sep 25;256(18):9750-4.
4
Stimulation of natural killer cell activity and inhibition of proliferation of various leukemic cells by purified human leukocyte interferon subtypes.纯化的人白细胞干扰素亚型对自然杀伤细胞活性的刺激及对各种白血病细胞增殖的抑制作用。
Cancer Res. 1982 Apr;42(4):1312-6.
5
Human leukocyte interferon produced by E. coli is biologically active.由大肠杆菌产生的人白细胞干扰素具有生物活性。
Nature. 1980 Oct 2;287(5781):411-6. doi: 10.1038/287411a0.
6
Human leukocyte and fibroblast interferons are structurally related.人白细胞干扰素和成纤维细胞干扰素在结构上相关。
Nature. 1980 Jun 19;285(5766):547-9. doi: 10.1038/285547a0.
7
The absence of introns within a human fibroblast interferon gene.人类成纤维细胞干扰素基因内不存在内含子。
Nucleic Acids Res. 1981 Jan 24;9(2):247-66. doi: 10.1093/nar/9.2.247.
8
Recombinant human leukocyte interferon produced in bacteria has antiproliferative activity.细菌产生的重组人白细胞干扰素具有抗增殖活性。
J Biol Chem. 1981 Mar 10;256(5):2113-4.
9
Antiviral activities of hybrids of two major human leukocyte interferons.两种主要人类白细胞干扰素杂交体的抗病毒活性
Nucleic Acids Res. 1981 Nov 25;9(22):6153-66. doi: 10.1093/nar/9.22.6153.
10
Specific molecular activities of recombinant and hybrid leukocyte interferons.重组和杂交白细胞干扰素的特定分子活性。
J Biol Chem. 1982 Oct 10;257(19):11497-502.

引用本文的文献

1
Construction, expression and characterization of human interferon alpha2b-(G4S)n-thymosin alpha1 fusion proteins in Pichia pastoris.人干扰素α2b-(G4S)n-胸腺素α1融合蛋白在毕赤酵母中的构建、表达及鉴定
World J Gastroenterol. 2005 May 7;11(17):2597-602. doi: 10.3748/wjg.v11.i17.2597.
2
Structure and properties of human interferon-alpha from Namalwa lymphoblastoid cells.来自Namalwa淋巴母细胞系的人α干扰素的结构与特性
Biochem J. 1982 Dec 1;207(3):397-408. doi: 10.1042/bj2070397.
3
A species of human alpha interferon that lacks the ability to boost human natural killer activity.一种缺乏增强人类自然杀伤细胞活性能力的人α干扰素。
Proc Natl Acad Sci U S A. 1984 Aug;81(15):4926-9. doi: 10.1073/pnas.81.15.4926.
4
Differential expression of human interferon genes.人类干扰素基因的差异表达
Nucleic Acids Res. 1984 May 11;12(9):3727-46. doi: 10.1093/nar/12.9.3727.
5
A new mass-spectrometric C-terminal sequencing technique finds a similarity between gamma-interferon and alpha 2-interferon and identifies a proteolytically clipped gamma-interferon that retains full antiviral activity.一种新的质谱C端测序技术发现γ干扰素与α2干扰素之间存在相似性，并鉴定出一种经蛋白酶切割但仍保留全部抗病毒活性的γ干扰素。
Biochem J. 1983 Nov 1;215(2):273-7. doi: 10.1042/bj2150273.
6
Nucleotide sequence of the transforming gene of m1 murine sarcoma virus.m1小鼠肉瘤病毒转化基因的核苷酸序列。
J Virol. 1984 Feb;49(2):579-82. doi: 10.1128/JVI.49.2.579-582.1984.
7
Orientation of a human leukocyte interferon molecule on its cell surface receptor: carboxyl terminus remains accessible to a monoclonal antibody made against a synthetic interferon fragment.人白细胞干扰素分子在其细胞表面受体上的取向：羧基末端对于针对合成干扰素片段制备的单克隆抗体仍可及。
Proc Natl Acad Sci U S A. 1983 May;80(9):2539-43. doi: 10.1073/pnas.80.9.2539.
8
The primary structure of the Saccharomyces cerevisiae gene for 3-phosphoglycerate kinase.酿酒酵母3-磷酸甘油酸激酶基因的一级结构。
Nucleic Acids Res. 1982 Dec 11;10(23):7791-808. doi: 10.1093/nar/10.23.7791.
9
Biologic activity in a fragment of recombinant human interferon alpha.重组人干扰素α片段中的生物活性。
Proc Natl Acad Sci U S A. 1984 Feb;81(4):1045-7. doi: 10.1073/pnas.81.4.1045.
10
Structure and expression of cloned murine IFN-alpha genes.克隆的小鼠α干扰素基因的结构与表达
Nucleic Acids Res. 1983 Feb 11;11(3):555-73. doi: 10.1093/nar/11.3.555.

本文引用的文献

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Virus interference. I. The interferon.病毒干扰。一、干扰素。
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Amino terminal sequence of the major component of human lymphoblastoid interferon.人淋巴母细胞样干扰素主要成分的氨基末端序列。
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New protein sequenator with increased sensitivity.灵敏度更高的新型蛋白质测序仪。
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4
Synthesis in E. coli of a polypeptide with human leukocyte interferon activity.在大肠杆菌中合成具有人白细胞干扰素活性的多肽。
Nature. 1980 Mar 27;284(5754):316-20. doi: 10.1038/284316a0.
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Manual Edman sequencing techniques for proteins and peptides at the nanomole level.
Methods Enzymol. 1981;79(Pt B):27-31. doi: 10.1016/s0076-6879(81)79010-4.
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Purification of recombinant human leukocyte interferon (IFLrA) with monoclonal antibodies.
Methods Enzymol. 1981;78(Pt A):505-12. doi: 10.1016/0076-6879(81)78162-x.
7
Purification of interferon produced in a culture of human granulocytes.
Methods Enzymol. 1981;78(Pt A):472-81. doi: 10.1016/0076-6879(81)78158-8.
8
Human leukocyte interferon: isolation and characterization of several molecular forms.人白细胞干扰素：几种分子形式的分离与特性
Arch Biochem Biophys. 1981 Aug;210(1):307-18. doi: 10.1016/0003-9861(81)90194-6.
9
Construction and identification of bacterial plasmids containing nucleotide sequence for human leukocyte interferon.含人白细胞干扰素核苷酸序列细菌质粒的构建与鉴定
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7010-3. doi: 10.1073/pnas.77.12.7010.
10
The structure of eight distinct cloned human leukocyte interferon cDNAs.八个不同克隆的人白细胞干扰素cDNA的结构。
Nature. 1981 Mar 5;290(5801):20-6. doi: 10.1038/290020a0.