人十二指肠内滴注胆汁后外分泌性胰腺分泌及免疫反应性促胰液素（IRS）释放情况
Exocrine pancreatic secretion and immunoreactive secretin (IRS) release after intraduodenal instillation of bile in man.
作者信息
Osnes M, Hanssen L E, Flaten O, Myren J
出版信息
Gut. 1978 Mar;19(3):180-4. doi: 10.1136/gut.19.3.180.
Abstract
Six subjects with a normal endoscopic pancreatogram were investigated after an overnight fast by means of a side-viewing duodenoscope. After cannulation of the main pancreatic duct, juice was collected in five-minute samples for 20 minutes. An iso-osmolar solution of 6 g cattle bile was then infused into the duodenum through a separate catheter attached to the outside of the duodenoscope, and pancreatic juice collected in five-minute samples for another 20 minutes. Blood was frequently drawn from an arm vein through an indwelling catheter for estimation of immunoreactive secretin (IRS) by radioimmunassay. The flow rate of pancreatic juice and outputs of bicarbonate, amylase, and protein increased significantly after intraduodenal infusion of bile. A significant rise in plasma IRS was also found after instillation of bile in the duodenum.
摘要
对6名内镜下胰管造影正常的受试者进行了研究，在禁食过夜后，使用侧视十二指肠镜进行检查。在主胰管插管后，每隔5分钟收集一次胰液样本，共收集20分钟。然后通过连接在十二指肠镜外部的单独导管，将6克牛胆汁的等渗溶液注入十二指肠，并每隔5分钟收集一次胰液样本，再收集20分钟。通过留置导管从手臂静脉频繁采血，采用放射免疫分析法测定免疫反应性促胰液素（IRS）。十二指肠内注入胆汁后，胰液流速以及碳酸氢盐、淀粉酶和蛋白质的分泌量均显著增加。在十二指肠内滴注胆汁后，血浆IRS也显著升高。
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本文引用的文献
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