Slack J, Noble N, Meade T W, North W R
Br Med J. 1977 Aug 6;2(6083):353-7. doi: 10.1136/bmj.2.6083.353.
Serum lipid and lipoprotein concentrations in men and women vary with age, and so-called "normal" limits should take account of this. Serum cholesterol, triglyceride, and phospholipid concentrations were measured in 1027 men and 577 women in five working populations in north-west London, and lipoprotein electrophoresis and quantitative analyses of lipoprotein concentrations were also performed. In men the best fit between serum cholesterol, triglycerides, and phospholipids, on the one hand, and age, on the other, was given by a curvilinear relationship expressed as a quadratic regression. In women the best fit was given by a linear regression. White men had higher serum cholesterol and triglyceride concentrations than Black men, and these differences were reflected in the distributions of the lipoproteins. There were no differences between values in White and Black women. Young women on oral contraceptives had lipid concentrations similar to those of older women not on these preparations. These data suggest that the adoption of concentrations of serum cholesterol (275-300 mg/100 ml (7-1-7-8 mmol/l) and triglycerides (175-200 mg/100 ml (2-0--2-3 mmol/l) recommended by a recent report on the prevention of coronary disease as limits above which special attention should be given to the management of hyperlipidaemia could result in as few as 2% of younger men or as many as 31% of older men being selected for treatment.
男性和女性的血清脂质及脂蛋白浓度随年龄而变化，因此所谓的“正常”范围应考虑到这一点。对伦敦西北部五个工作人群中的1027名男性和577名女性进行了血清胆固醇、甘油三酯和磷脂浓度的测量，同时还进行了脂蛋白电泳及脂蛋白浓度的定量分析。在男性中，血清胆固醇、甘油三酯和磷脂与年龄之间的最佳拟合关系呈曲线关系，可用二次回归表示。在女性中，最佳拟合关系为线性回归。白人男性的血清胆固醇和甘油三酯浓度高于黑人男性，这些差异反映在脂蛋白的分布上。白人女性和黑人女性的值没有差异。服用口服避孕药的年轻女性的脂质浓度与未服用这些药物的老年女性相似。这些数据表明，采用最近一份关于冠心病预防的报告中建议的血清胆固醇浓度（275 - 300 mg/100 ml（7.1 - 7.8 mmol/l））和甘油三酯浓度（175 - 200 mg/100 ml（2.0 - 2.3 mmol/l））作为上限，超过此上限就应特别关注高脂血症的管理，那么可能只有2%的年轻男性或多达31%的老年男性会被选作治疗对象。
