Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics and Obesity group), University of the Balearic Islands, 07122, Palma, Spain.
Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy and Lucio Lascaray Research Center, University of the Basque Country (UPV/EHU), Vitoria, Spain.
Sci Rep. 2018 Oct 10;8(1):15100. doi: 10.1038/s41598-018-32875-4.
We aimed to assess the potential effects of hesperidin and capsaicin, independently and in combination, to prevent the development of obesity and its related metabolic alterations in rats fed an obesogenic diet. Three-month-old male Wistar rats were divided into 5 groups: Control (animals fed a standard diet), WD (animals fed a high fat/sucrose (western) diet), HESP (animals fed a western diet + hesperidin (100 mg/kg/day)), CAP (animals fed a western diet + capsaicin (4 mg/kg/day)), and HESP + CAP (animals fed a western diet + hesperidin (100 mg/kg/day) + capsaicin (4 mg/kg/day)). Hesperidin and capsaicin were administered by gavage. Capsaicin decreased body fat gain and prevented insulin resistance, whereas hesperidin showed little effect on body fat gain and no apparent effects on insulin resistance. No additive effects were observed with the combination. Capsaicin and hesperidin, separately, improved blood lipid profile, diminished hepatic lipid accumulation, and prevented non-alcoholic steatohepatitis in western diet-fed rats, but the combination showed lower effects. Hesperidin alone, and to a lesser extent capsaicin or the combination, displayed hypotensive effects in western diet-fed rats. In conclusion, capsaicin and hesperidin, separately, exhibit health beneficial effects on metabolic syndrome-related alterations in western diet-fed rats, but the effects are mitigated with the combination.
我们旨在评估橙皮苷和辣椒素单独及联合使用对预防肥胖及其相关代谢改变的潜在影响，这些作用发生在给予致肥胖饮食的大鼠中。将 3 月龄雄性 Wistar 大鼠分为 5 组：对照组（给予标准饮食的动物）、WD 组（给予高脂肪/蔗糖（西式）饮食的动物）、HESP 组（给予西式饮食+橙皮苷（100mg/kg/天）的动物）、CAP 组（给予西式饮食+辣椒素（4mg/kg/天）的动物）和 HESP+CAP 组（给予西式饮食+橙皮苷（100mg/kg/天）+辣椒素（4mg/kg/天）的动物）。橙皮苷和辣椒素通过灌胃给药。辣椒素降低了体脂增加并预防了胰岛素抵抗，而橙皮苷对体脂增加几乎没有影响，也没有明显的胰岛素抵抗作用。联合使用没有观察到相加作用。辣椒素和橙皮苷单独使用均可改善血脂谱，减少肝脂质蓄积，并预防西式饮食喂养大鼠的非酒精性脂肪性肝炎，但联合使用效果较低。单独的橙皮苷，以及程度较小的辣椒素或联合使用，在给予西式饮食的大鼠中显示出降压作用。总之，辣椒素和橙皮苷单独使用时对西式饮食喂养大鼠的代谢综合征相关改变具有有益的健康作用，但联合使用时作用减轻。
