Farhan Ahmed, Alsuwayt Bader, Alanazi Farhan, Yaseen Abdulhadi, Ashour Mohamed A
Department of Clinical Pharmacy, Faculty of Pharmacy, Northern Border University, Rafha, KSA.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Northern Border University, Rafha, KSA.
J Taibah Univ Med Sci. 2020 Dec 13;16(2):152-161. doi: 10.1016/j.jtumed.2020.10.023. eCollection 2021 Apr.
Burn injuries are among the most common accidental health problems worldwide, frequently leading to health and socio-economic challenges. Despite this, no standard protocol for managing burn injuries can overcome the adverse effects of currently used drugs. The present study sets out to develop and evaluate the efficacy of new herbal ointments in providing synergistic anti-inflammatory, antimicrobial, antioxidant, and cell-proliferating activities. It also investigates the high-performance liquid chromatography (HPLC) characterisation of these new herbal ointments.
Three different concentrations of the new herbal ointment, which incorporates extracts of flower heads, arial parts of , leaves, roots, and myrrh were developed and evaluated. Ointments designed to promote burn-wound healing were prepared and compared with β-sitosterol ointment and silver sulfadiazine cream, as a commercial standards.
According to statistical and histopathological analyses and visual inspections, the new herbal formulas showed faster wound healing, more tolerability, and less toxicity than the commercial standards.
The new herbal ointments, developed in our study, have shown promising results. The formula offers mechanical protection without any release of non-biodegradable particles. It maintains the optimum moisture and pH of the skin, while minimising scar-tissue formation. These advantages, in addition to availability, low costs, and easy handling, may support the use of this new herbal formula as an effective and safe alternative treatment, designed to promote the healing of burn injuries.
烧伤是全球最常见的意外健康问题之一，常常导致健康和社会经济方面的挑战。尽管如此，目前尚无用于治疗烧伤的标准方案能够克服现有药物的不良影响。本研究旨在开发并评估新型草药软膏在提供协同抗炎、抗菌、抗氧化和细胞增殖活性方面的功效。同时还对这些新型草药软膏进行高效液相色谱（HPLC）表征研究。
研发并评估了三种不同浓度的新型草药软膏，其包含了花头提取物、[植物名称]地上部分、[植物名称]叶、[植物名称]根以及没药。制备了旨在促进烧伤创面愈合的软膏，并与作为商业标准的β-谷甾醇软膏和磺胺嘧啶银乳膏进行比较。
根据统计分析、组织病理学分析和外观检查，新型草药配方显示出比商业标准更快的伤口愈合速度、更高的耐受性和更低的毒性。
我们研究中开发的新型草药软膏已显示出有前景的结果。该配方提供机械保护，且不会释放任何不可生物降解的颗粒。它能维持皮肤的最佳水分和pH值，同时将瘢痕组织形成降至最低。除了可用性、低成本和易于操作外，这些优势可能支持将这种新型草药配方用作促进烧伤愈合的有效且安全的替代治疗方法。
